Abstract:

Idiopathic thrombocytopenic purpura (ITP) in pregnancy is an autoimmune disease, which is the most common cause of thrombocytopenia in early pregnancy. Due to the specific binding of antiplatelet antibodies in maternal plasma to platelets and the deficiency of T cells gene expression, the megakaryocyte maturation disorder, increased platelet destruction and insufficient production are induced. However, the exact pathogenesis is not clear yet. Severe ITP increases the risk of adverse pregnancy outcomes of mothers and infants, such as spontaneous haemorrhage during pregnancy, anemia, postpartum hemorrhage, premature birth and neonatal thrombocytopenia. At present, it is difficult to deal with severe ITP. The first-line treatment is mainly oral corticosteroids and intravenous immunoglobulin. When the first-line treatment fails, the effective second-line treatment and timely obstetric treatment will be particularly important, for example, splenectomy, platelet transfusion and thrombopoietin drugs, etc. This review summarized the pathogenesis, treatment and the maternal and infant outcomes of severe ITP during pregnancy.

Key words: Purpura,thrombocytopenic,idiopathic, Pregnancy, Pathogenesis, Therapy, Pregnancy outcome