Research Progress of Cyclosporine A Treatment of Recurrent Spontaneous Abortion

doi:10.12280/gjszjk.20210233

Abstract

Abstract:

Recurrent spontaneous abortion (RSA) is a common gynecological and obstetric disease. The etiology of RSA is complex, while the etiology of some RSA patients is still unclear, which may be closely related to abnormal immune factors. The therapeutic effect of cellular immunosuppressant cyclosporine A (CsA) in recurrent abortion has been gradually revealed. It has been found that CSA can regulate the maternal-fetal immune tolerance and trophoblast proliferation, migration and invasion, which provides evidence support for its use as a drug related to RSA. In this paper, we expound the embryonic protection mechanism of CsA from the various aspects. CsA participates in regulating the balance of maternal and fetal immune tolerance cytokines, alleviating the immune stress injury of trophoblast, enhancing the proliferation and invasion of trophoblast and reducing trophoblast apoptosis. Combined with the latest clinical reports on the CsA combined with traditional Chinese medicine in the treatment of RSA, we discuss the treatment application of CsA in RSA diseases, and provide ideas for further research on CsA in the treatment of RSA.

Key words: Cyclosporine A, Cyclosporins, Immune tolerance, Trophoblasts, Abortion, habitual

GE Meng-di, ZHAO Xiao-xuan, ZHAO Yan, FENG Xiao-ling. Research Progress of Cyclosporine A Treatment of Recurrent Spontaneous Abortion[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(6): 514-518.

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