Autophagy Participated in Pathological Mechanism of Premature Ovarian Insufficiency

doi:10.12280/gjszjk.20220133

Abstract

Abstract:

The combination of factors of premature ovarian insufficiency (POI) may include chromosomal abnormalities, autoimmune diseases, chemotherapy, environmental pollutants and so on. Autophagy as a kind of important mechanisms for maintaining cellular homeostasis and energy balance is associated with the occurrence and development of POI. The autophagy defect related to chromosomal abnormalities and gene mutations may lead to a large number of primordial follicles loss and the restraint of granulosa cell differentiation, which injures ovarian function, and finally leads to POI. The excessive activation of autophagy caused by stimulation of adverse factors in ovarian cells, such as autoimmune diseases, chemotherapy and environmental pollutants, leads to the apoptosis of ovarian cells and the increase of atresia follicles, which reduces primordial follicles, and finally leads to POI. In this paper, the effect of autophage in the pathogenesis of POI was reviewed, in order to discusse how to improve ovarian function of POI patients in clinical practice.

Key words: Premature ovarian insufficiency, Autophagy, Chromosome aberrations, Autoimmune diseases, Antineoplastic combined chemotherapy protocols

YAO Ting, YANG Hong-mei, CUI Li-hua, MENG Qing-fang. Autophagy Participated in Pathological Mechanism of Premature Ovarian Insufficiency[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(4): 313-316.

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