Advances of Stem Cell Therapy for Endometrial Injuries

doi:10.12280/gjszjk.20220179

Abstract

Abstract:

Endometrial injuries caused by infection or intrauterine hinders the implantation and development of embryos, and seriously affects women′s physical and mental health and their fertility. However, the current treatment approaches are limited and ineffective. Stem cells play an important role in repairing the damaged tissue due to their self-renewal capacity and differentiation potential. The cells used in the stem cells therapy, such as bone mesenchymal stem cells (MSCs), umbilical cord mesenchymal stem cells (UC-MSCs), endometrial stem cells (EnScs), adipose-derived stem cells (ASCs) and human amniotic epithelial cells (hAECs) have been shown the great potential for endometrial injury treatment in the animal models and clinical studies. Stem cell therapy promotes the regeneration of endometrial cells, thereby improving the endometrial thickness and microvessel density, as well as increasing the conception rate and improving the fertility outcome. Stem cell therapy may improve the endometrium morphologically and functionally, and help to restore the menstrual and reproductive functions, providing a new therapeutic strategy for endometrial injuries.

Key words: Endometrium, Wounds and injuries, Uterus, Tissue adhesions, Stem cells, Therapy

SHEN Yan-qing, CHEN Huang, CHEN Ye. Advances of Stem Cell Therapy for Endometrial Injuries[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(4): 322-326.

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