Visual Analysis of Recurrent Spontaneous Miscarriage Based on the Web of Science Database over the Last 10 Years

doi:10.12280/gjszjk.20220210

Abstract

Abstract:

Objective: To analyze the research status and development trend of recurrent spontaneous miscarriage(RSA) using the Web of Science core collection database and knowledge graphs. Methods: The Web of Science core collection database was searched for topics on recurrent miscarriages between January, 2012 and January, 2022. The scientometric tools CiteSpace (version 5.8.R3) and VOSviewer (version 1.6.17) were then used to visually analyze the publishing countries, institutions, authors, keywords, and cited papers for RSA. Results: A total of 3 116 articles were retrieved. After de-weighting and transformation, 3 116 articles were included. The countries with the most publications were China, USA and UK; the main research institutions were Shanghai Jiaotong University and Fudan University; the most cited literature with the highest centrality was mainly related to RSA of unknown origin; the high frequency keywords were mainly expression, risk factor and natural killer cell. Conclusions: The etiology of RSA is complex and the pathogenesis is unknown. More attention is currently paid to maternal-fetal immune tolerance balance, while other etiologies such as genetic factors and pre-thrombotic states should also be studied in depth.

Key words: Abortion, habitual, CiteSpace, VOSviewer, Visualization, Web of Science

PAN Wan-qing, ZHANG Yi-jie, WEI Wei-feng, HU Xiao-fang. Visual Analysis of Recurrent Spontaneous Miscarriage Based on the Web of Science Database over the Last 10 Years[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(5): 375-381.

Figures/Tables 10

References 26

[1]	自然流产诊治中国专家共识编写组. 自然流产诊治中国专家共识(2020年版)[J]. 中国实用妇科与产科杂志, 2020, 36(11):1082-1090. doi: 10.19538/j.fk2020110113. doi: 10.19538/j.fk2020110113
[2]	Christiansen OB, Nybo Andersen AM, Bosch E, et al. Evidence-based investigations and treatments of recurrent pregnancy loss[J]. Fertil Steril, 2005, 83(4):821-839. doi: 10.1016/j.fertnstert.2004.12.018. doi: 10.1016/j.fertnstert.2004.12.018 pmid: 15820784
[3]	张清华, 潘静, 姚丽艳. 复发性流产患者病因构成分析[J]. 中国全科医学, 2020, 23(14):1760-1764. doi: 10.12114/j.issn.1007-9572.2019.00.738. doi: 10.12114/j.issn.1007-9572.2019.00.738
[4]	Wu M, Liu P, Cheng L. Galectin-1 reduction and changes in T regulatory cells may play crucial roles in patients with unexplained recurrent spontaneous abortion[J]. Int J Clin Exp Pathol, 2015, 8(2):1973-1978.
[5]	Chen C. CiteSpace II: Detecting and visualizing emerging trends[J]. J Am Soc Inf Sci Te, 2006, 57(3):359-377. doi: 10.1002/asi.20317. doi: 10.1002/asi.20317
[6]	van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping[J]. Scientometrics, 2010, 84(2):523-538. doi: 10.1007/s11192-009-0146-3. doi: 10.1007/s11192-009-0146-3 pmid: 20585380
[7]	王亚辉, 袁天蔚, 李大金. 女性生殖医学研究热点——基于科学知识图谱的文献计量分析[J]. 中华生殖与避孕杂志, 2021, 41(5):467-476. doi: 10.3760/cma.j.cn101441-20200312-00125. doi: 10.3760/cma.j.cn101441-20200312
[8]	ESHRE Guideline Group on RPL, Bender Atik R, Christiansen OB, et al. ESHRE guideline: recurrent pregnancy loss[J]. Hum Reprod Open, 2018, 2018(2): hoy004. doi: 10.1093/hropen/hoy004. doi: 10.1093/hropen/hoy004
[9]	Practice Committee of the American Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss: a committee opinion[J]. Fertil Steril, 2013, 99:63. doi: 10.1016/j.fertnstert.2012.09.023.. doi: S0015-0282(12)02242-X pmid: 23095139
[10]	Pracetice Committee of the American Society for Reproductive Medicine. Evaluation and treatment of recurrent pregnancy loss: a committee opinion[J]. Fertil Steril, 2013, 98(5): 1103-1111. doi: 10.1016/j.fertnstert.2012.06.048. doi: 10.1016/j.fertnstert.2012.06.048 URL
[11]	El Hachem H, Crepaux V, May-Panloup P, et al. Recurrent pregnancy loss: current perspectives[J]. Int J Womens Health, 2017, 9:331-345. doi: 10.2147/IJWH.S100817. doi: 10.2147/IJWH.S100817 pmid: 28553146
[12]	Kaandorp SP, Goddijn M, van der Post JA, et al. Aspirin plus heparin or aspirin alone in women with recurrent miscarriage[J]. N Engl J Med, 2010, 362(17):1586-1596. doi: 10.1056/NEJMoa1000641. doi: 10.1056/NEJMoa1000641 URL
[13]	Seshadri S, Sunkara SK. Natural killer cells in female infertility and recurrent miscarriage: a systematic review and meta-analysis[J]. Hum Reprod Update, 2014, 20(3):429-438. doi: 10.1093/humupd/dmt056. doi: 10.1093/humupd/dmt056 pmid: 24285824
[14]	Coomarasamy A, Williams H, Truchanowicz E, et al. A Randomized Trial of Progesterone in Women with Recurrent Miscarriages[J]. N Engl J Med, 2015, 373(22):2141-2148. doi: 10.1056/NEJMoa1504927. doi: 10.1056/NEJMoa1504927 URL
[15]	Liu Z, Xu H, Kang X, et al. Allogenic Lymphocyte Immunotherapy for Unexplained Recurrent Spontaneous Abortion: A Meta-Analysis[J]. Am J Reprod Immunol, 2016, 76(6):443-453. doi: 10.1111/aji.12511. doi: 10.1111/aji.12511 URL
[16]	Alijotas-Reig J, Llurba E, Gris JM. Potentiating maternal immune tolerance in pregnancy: A new challenging role for regulatory T cells[J]. Placenta, 2014, 35(4):241-248. doi: 10.1016/j.placenta.2014.02.004. doi: 10.1016/j.placenta.2014.02.004 pmid: 24581729
[17]	Quenby S, Gallos ID, Dhillon-Smith RK, et al. Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss[J]. Lancet, 2021, 397(10285):1658-1667. doi: 10.1016/S0140-6736(21)00682-6. doi: 10.1016/S0140-6736(21)00682-6 pmid: 33915094
[18]	Wang S, Li M, Sun F, et al. Th17/Treg-cell balance in the peripheral blood of pregnant females with a history of recurrent spontaneous abortion receiving progesterone or cyclosporine A[J]. Exp Ther Med, 2021, 21(1):37. doi: 10.3892/etm.2020.9469. doi: 10.3892/etm.2020.9469 pmid: 33273967
[19]	Toth B, Würfel W, Bohlmann M, et al. Recurrent Miscarriage: Diagnostic and Therapeutic Procedures. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry Number 015/050)[J]. Geburtshilfe Frauenheilkd, 2018, 78(4):364-381. doi: 10.1055/a-0586-4568. doi: 10.1055/a-0586-4568 URL
[20]	Kwak-Kim J, Ota K, Sung N, et al. COVID-19 and immunomodulation treatment for women with reproductive failures[J]. J Reprod Immunol, 2020, 141:103168. doi: 10.1016/j.jri.2020.103168. doi: 10.1016/j.jri.2020.103168 URL
[21]	Ander SE, Diamond MS, Coyne CB. Immune responses at the maternal-fetal interface[J]. Sci Immunol, 2019, 4(31):eaat6114. doi: 10.1126/sciimmunol.aat6114. doi: 10.1126/sciimmunol.aat6114 URL
[22]	Koopman LA, Kopcow HD, Rybalov B, et al. Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential[J]. J Exp Med, 2003, 198(8):1201-1212. doi: 10.1084/jem.20030305. doi: 10.1084/jem.20030305 pmid: 14568979
[23]	Helige C, Ahammer H, Moser G, et al. Distribution of decidual natural killer cells and macrophages in the neighbourhood of the trophoblast invasion front: a quantitative evaluation[J]. Hum Reprod, 2014, 29(1):8-17. doi: 10.1093/humrep/det353. doi: 10.1093/humrep/det353 URL
[24]	Liu S, Diao L, Huang C, et al. The role of decidual immune cells on human pregnancy[J]. J Reprod Immunol, 2017, 124:44-53. doi: 10.1016/j.jri.2017.10.045. doi: S0165-0378(17)30132-8 pmid: 29055791
[25]	Wu L, Li J, Xu HL, et al. IL-7/IL-7R signaling pathway might play a role in recurrent pregnancy losses by increasing inflammatory Th17 cells and decreasing Treg cells[J]. Am J Reprod Immunol, 2016, 76(6):454-464. doi: 10.1111/aji.12588. doi: 10.1111/aji.12588 URL
[26]	Yang Y, Cheng L, Deng X, et al. Expression of GRIM-19 in unexplained recurrent spontaneous abortion and possible pathogenesis[J]. Mol Hum Reprod, 2018, 24(7):366-374. doi: 10.1093/molehr/gay020. doi: 10.1093/molehr/gay020 pmid: 29741731

排序	高频关键词	频次	中心度
1	expression	460	0.02
2	risk factor	406	0.02
3	natural killer cell	298	0.01
4	regulatory T cell	295	0.01
5	association	237	0.02
6	in vitro fertilization	218	0.01
7	cell	161	0.03
8	peripheral blood	142	0.02
9	polymorphism	140	0.03
10	implantation	138	0.02
11	antiphospholipid syndrome	130	0.02
12	preeclampsia	119	0.02
13	fetal loss	119	0.02
14	antiphospholipid antibody	113	0.02
15	gene	105	0.03
16	low molecular weight heparin	101	0.02

排序	高频关键词	频次	中心度
1	expression	460	0.02
2	risk factor	406	0.02
3	natural killer cell	298	0.01
4	regulatory T cell	295	0.01
5	association	237	0.02
6	in vitro fertilization	218	0.01
7	cell	161	0.03
8	peripheral blood	142	0.02
9	polymorphism	140	0.03
10	implantation	138	0.02
11	antiphospholipid syndrome	130	0.02
12	preeclampsia	119	0.02
13	fetal loss	119	0.02
14	antiphospholipid antibody	113	0.02
15	gene	105	0.03
16	low molecular weight heparin	101	0.02

聚类	S值	关键词
#0 Meta analysis	0.882	double blind、prevention、multicenter、trophoblast cells
#1 Treg cells	0.874	receptor、vascular endothelial growth factor、trophoblasts、Th17 cells
#2 Growth	0.906	mice、cytokine、embryo implantation、reproductive immunology
#3 DNA fragmentation	0.961	male infertility、sperm dna fragmentation、varicocele、sperm
#4 Natural killer cells	0.958	NK cell、regulatory T cells、peripheral blood
#5 Aneuploidy	0.905	comparative genomic hybridization、balanced translocation、preimplantation genetic screening、karyotyping
#6 Apoptosis	0.835	expression、hydatidiform mole、gene、microRNA
#7 Antiphospholipid syndrome	0.867	antiphospholipid antibodies、aspirin、heparin、pregnancy complications

聚类	S值	关键词
#0 Meta analysis	0.882	double blind、prevention、multicenter、trophoblast cells
#1 Treg cells	0.874	receptor、vascular endothelial growth factor、trophoblasts、Th17 cells
#2 Growth	0.906	mice、cytokine、embryo implantation、reproductive immunology
#3 DNA fragmentation	0.961	male infertility、sperm dna fragmentation、varicocele、sperm
#4 Natural killer cells	0.958	NK cell、regulatory T cells、peripheral blood
#5 Aneuploidy	0.905	comparative genomic hybridization、balanced translocation、preimplantation genetic screening、karyotyping
#6 Apoptosis	0.835	expression、hydatidiform mole、gene、microRNA
#7 Antiphospholipid syndrome	0.867	antiphospholipid antibodies、aspirin、heparin、pregnancy complications