Case Report of Pregnancy in Two Patients with Diminished Ovarian Reserve Treated with Traditional and Western Medicine, and Literature Review

doi:10.12280/gjszjk.20220234

Abstract

Abstract:

The diminished ovarian reserve (DOR) is one of the main causes of infertility caused by ovarian factors. The clinical treatment with Western Medicine mainly relies on the oral drugs to improve the ovarian reserve function, artificial hormone cycle replacement and assisted reproductive technology to help pregnancy. The method of Tonifying Kidney and Strengthen Spleen Therapy in Traditional Chinese Medicine (TCM) has many advantages in improving the ovarian reserve function, such as low adverse reactions, long-lasting curative effect and diversified methods. In this article, two cases of DOR patients were reported who were successfully treated with the comprehensive treatment of Tonifying Kidney and Strengthen Spleen Therapy of TCM on the basis of conventional Western Medicine. We emphasized the importance of formulating a targeted and individualized treatment plan of the integrated TCM and Western Medicine for solving difficult diseases. This article provides a new evidence of the comprehensive treatment with TCM and Western Medicine in DOR patients.

Key words: Ovarian reserve, Primary ovarian insufficiency, TCM therapy, Reinforcing kidney, Strengthen spleen, Pregnancy, Case reports

ZHANG Yu, XIA Tian. Case Report of Pregnancy in Two Patients with Diminished Ovarian Reserve Treated with Traditional and Western Medicine, and Literature Review[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(6): 460-463.

References 13

[1]	Committee opinion no.605: primary ovarian insufficiency in adolescents and young women[J]. Obstet Gynecol, 2014, 124(1):193-197. doi: 10.1097/01.AOG.0000451757.51964.98 doi: 10.1097/01.AOG.0000451757.51964.98 URL
[2]	卵巢储备功能减退临床诊治专家共识专家组, 中华预防医学会生育力保护分会生殖内分泌生育保护学组. 卵巢储备功能减退临床诊治专家共识[J]. 生殖医学杂志, 2022, 31(4):425-434. doi:10.3969/j.issn.1004-3845.2022.04.001. doi: 10.3969/j.issn.1004-3845.2022.04.001
[3]	Ferraretti AP, La Marca A, Fauser BC, et al. ESHRE consensus on the definition of ′poor response′ to ovarian stimulation for in vitro fertilization: the Bologna criteria[J]. Hum Reprod, 2011, 26(7):1616-1624. doi: 10.1093/humrep/der092. doi: 10.1093/humrep/der092 URL
[4]	裴佳欢, 刘丝荪, 王芬. 卵巢储备功能下降的治疗进展[J]. 江西医药, 2021, 56(8):1309-1312. doi: 10.3969/j.issn.1006-2238.2021.08.072. doi: 10.3969/j.issn.1006-2238.2021.08.072
[5]	吕爱霞, 秦红平, 莫少康, 等. 卵巢储备功能低下患者补充脱氢表雄酮后诱导排卵的临床研究[J]. 生殖医学杂志, 2022, 31(1):58-62. doi: 10.3969/j.issn.1004-3845.2022.01.010. doi: 10.3969/j.issn.1004-3845.2022.01.010
[6]	庄虔莹, 王芹, 陈仝, 等. 脱氢表雄酮对卵巢储备功能减退患者IVF结局及卵泡液GDF-9、BMP-15的影响[J]. 首都医科大学学报, 2021, 42(2):188-193. doi: 10.3969/j.issn.1006-7795.2021.02.004. doi: 10.3969/j.issn.1006-7795.2021.02.004
[7]	Aramesh S, Alifarja T, Jannesar R, et al. Does vitamin D supplementation improve ovarian reserve in women with diminished ovarian reserve and vitamin D deficiency: a before-and-after intervention study[J]. BMC Endocr Disord, 2021, 21(1):126. doi: 10.1186/s12902-021-00786-7. doi: 10.1186/s12902-021-00786-7 pmid: 34154571
[8]	邹宇洁, 尹太郎, 李洁, 等. 辅酶Q10联合维生素E对高龄女性卵巢功能及IVF结局的影响[J]. 生殖医学杂志, 2017, 26(10):1028-1034. doi: 10.3969/j.issn.1004-3845.2017.10.014. doi: 10.3969/j.issn.1004-3845.2017.10.014
[9]	葛任洁, 胡荣魁, 陈昊, 等. 卵巢储备功能下降的中医药诊治进展[J]. 中华中医药杂志, 2020, 35(1):322-325. doi: 10.13194/j.issn.1673-842x.2017.01.026. doi: 10.13194/j.issn.1673-842x.2017.01.026
[10]	滕秀香, 李培培, 姚海洋, 等. “益肾疏肝汤”联合人工周期疗法治疗卵巢早衰肾虚肝郁证的临床研究[J]. 辽宁中医杂志, 2016, 43(1):93-96. doi: 10.13192/j.issn.1000-1719.2016.01.039. doi: 10.13192/j.issn.1000-1719.2016.01.039
[11]	梁学梅, 闫颖. 中医治疗卵巢储备功能下降研究进展[J]. 时珍国医国药, 2021, 32(7):1720-1723. doi: 10.3969/j.issn.1008-0805.2021.07.53. doi: 10.3969/j.issn.1008-0805.2021.07.53
[12]	唐文龙, 胡雨华, 何晓华. 经脉排刺治疗阴阳两虚型卵巢储备功能下降的临床研究[J]. 针刺研究, 2015, 40(6):479-483,488. doi: 10.13702/j.1000-0607.2015.06.010. doi: 10.13702/j.1000-0607.2015.06.010
[13]	周莉, 夏有兵, 马翔, 等. 针灸序贯疗法对卵巢储备功能下降患者IVF-ET的影响[J]. 中国针灸, 2016, 36(1):25-28. doi: 10.13703/j.0255-2930.2016.01.007. doi: 10.13703/j.0255-2930.2016.01.007

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