Application Progress of Indocyanine Green Fluorescence Imaging Technique in Radical Resection of Cervical Cancer

doi:10.12280/gjszjk.20220354

Abstract

Abstract:

Cervical cancer is one of the most common malignant tumors of reproductive system in China. Radical surgery is the main treatment of early cervical cancer. However, the scope of operation is wide and the technical difficulty is high. There may be many postoperative complications. The indocyanine green (ICG) fluorescence imaging technique has been widely used in surgery, and more and more studies have shown that it also shows a great application prospect in the radical resection of cervical cancer. This technique may play an active role in tracing sentinel lymph nodes, identifying pelvic nerve, evaluating uterine blood perfusion, protecting ureter and so on. This can not only improve the accuracy of intraoperative tumor resection, but also achieve the visualization of important anatomical structures, further reduce postoperative complications and improve prognosis, which can bring great benefits to patients. However, the application of ICG fluorescence imaging technique in the surgical treatment of cervical cancer is still in the initial stage. The safety and effectiveness of this technique need to be tested by the more application in clinical practice.

Key words: Uterine cervical neoplasms, Hysterectomy, Indocyanine green, Optical imaging, Therapy

JIANG Si-yue, WANG Wen-hua, ZENG Chao, CHEN Xi, YANG Yong-xiu. Application Progress of Indocyanine Green Fluorescence Imaging Technique in Radical Resection of Cervical Cancer[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(6): 524-528.

References 36

[1]	Arbyn M, Weiderpass E, Bruni L, et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis[J]. Lancet Glob Health, 2020, 8(2):e191-e203. doi: 10.1016/S2214-109X(19)30482-6. doi: 10.1016/S2214-109X(19)30482-6
[2]	中国抗癌协会妇科肿瘤专业委员会. 子宫颈癌诊断与治疗指南(2021年版)[J]. 中国癌症杂志, 2021, 31(6):474-489. doi: 10.19401/j.cnki.1007-3639.2021.06.06. doi: 10.19401/j.cnki.1007-3639.2021.06.06
[3]	张清泉, 王世军. 宫颈癌淋巴结的评估与手术策略探讨[J]. 中国全科医学, 2022, 25(18):2235-2238. doi: 10.12114/j.issn.1007-9572.2021.02.111. doi: 10.12114/j.issn.1007-9572.2021.02.111
[4]	Frumovitz M, Plante M, Lee PS, et al. Near-infrared fluorescence for detection of sentinel lymph nodes in women with cervical and uterine cancers (FILM): a randomised, phase 3, multicentre, non-inferiority trial[J]. Lancet Oncol, 2018, 19(10):1394-1403. doi: 10.1016/S1470-2045(18)30448-0. doi: S1470-2045(18)30448-0 pmid: 30143441
[5]	中国研究型医院学会妇产科学专业委员会. 子宫颈癌前哨淋巴结活检临床应用中国专家共识[J]. 中华肿瘤杂志, 2021, 43(10):981-988. doi: 10.3760/cma.j.cn112152-20210720-00526. doi: 10.3760/cma.j.cn112152-20210720-00526
[6]	舒桐, 李斌, 赵丹, 等. 基于新鲜尸体的盆腔自主神经平面的解剖学及组织学研究[J]. 中华妇产科杂志, 2022, 57(6):426-434. doi: 10.3760/cma.j.cn112141-20220505-00296. doi: 10.3760/cma.j.cn112141-20220505-00296
[7]	Zapardiel I, Alvarez J, Barahona M, et al. Utility of Intraoperative Fluorescence Imaging in Gynecologic Surgery: Systematic Review and Consensus Statement[J]. Ann Surg Oncol, 2021, 28(6):3266-3278. doi: 10.1245/s10434-020-09222-x. doi: 10.1245/s10434-020-09222-x pmid: 33095359
[8]	Moukarzel LA, Feinberg J, Levy EJ, et al. Current and novel mapping substances in gynecologic cancer care[J]. Int J Gynecol Cancer, 2020, 30(3):387-393. doi: 10.1136/ijgc-2019-001078. doi: 10.1136/ijgc-2019-001078 pmid: 31953349
[9]	Dip F, Boni L, Bouvet M, et al. Consensus Conference Statement on the General Use of Near-infrared Fluorescence Imaging and Indocyanine Green Guided Surgery: Results of a Modified Delphi Study[J]. Ann Surg, 2022, 275(4):685-691. doi: 10.1097/SLA.0000000000004412. doi: 10.1097/SLA.0000000000004412 URL
[10]	Zhang Z, He K, Chi C, et al. Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China[J]. Eur J Nucl Med Mol Imaging, 2022, 49(8):2531-2543. doi: 10.1007/s00259-022-05730-y. doi: 10.1007/s00259-022-05730-y URL
[11]	Ma R, Alifu N, Du Z, et al. Indocyanine Green-Based Theranostic Nanoplatform for NIR Fluorescence Image-Guided Chemo/Photothermal Therapy of Cervical Cancer[J]. Int J Nanomedicine, 2021, 16:4847-4861. doi: 10.2147/IJN.S318678. doi: 10.2147/IJN.S318678 URL
[12]	Xu D, Li L, Chu C, et al. Advances and perspectives in near-infrared fluorescent organic probes for surgical oncology[J]. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2020, 12(5):e1635. doi: 10.1002/wnan.1635. doi: 10.1002/wnan.1635
[13]	Mieog J, Achterberg FB, Zlitni A, et al. Fundamentals and developments in fluorescence-guided cancer surgery[J]. Nat Rev Clin Oncol, 2022, 19(1):9-22. doi: 10.1038/s41571-021-00548-3. doi: 10.1038/s41571-021-00548-3 URL
[14]	FOX IJ, WOOD EH. Indocyanine green: physical and physiologic properties[J]. Proc Staff Meet Mayo Clin, 1960, 35:732-744. pmid: 13701100
[15]	朱丽君, 张琳雪, 周明璋, 等. 有机荧光探针辅助的近红外荧光成像技术在宫颈癌中的应用[J]. 生物工程学报, 2021, 37(8):2678-2687. doi: 10.13345/j.cjb.200608. doi: 10.13345/j.cjb.200608
[16]	Lührs O, Bollino M, Ekdahl L, et al. Similar distribution of pelvic sentinel lymph nodes and nodal metastases in cervical and endometrial cancer. A prospective study based on lymphatic anatomy[J]. Gynecol Oncol, 2022, 165(3):466-471. doi: 10.1016/j.ygyno.2022.03.027. doi: 10.1016/j.ygyno.2022.03.027 pmid: 35437170
[17]	Lührs O, Ekdahl L, Lönnerfors C, et al. Combining Indocyanine Green and Tc(99)-nanocolloid does not increase the detection rate of sentinel lymph nodes in early stage cervical cancer compared to Indocyanine Green alone[J]. Gynecol Oncol, 2020, 156(2):335-340. doi: 10.1016/j.ygyno.2019.11.026. doi: 10.1016/j.ygyno.2019.11.026 URL
[18]	Baeten I, Hoogendam JP, Jeremiasse B, et al. Indocyanine green versus technetium-99m with blue dye for sentinel lymph node detection in early-stage cervical cancer: A systematic review and meta-analysis[J]. Cancer Rep(Hoboken), 2022, 5(1):e1401. doi: 10.1002/cnr2.1401. doi: 10.1002/cnr2.1401
[19]	Wang LG, Barth CW, Kitts CH, et al. Near-infrared nerve-binding fluorophores for buried nerve tissue imaging[J]. Sci Transl Med, 2020, 12(542):eaay0712. doi: 10.1126/scitranslmed.aay0712. doi: 10.1126/scitranslmed.aay0712 URL
[20]	Walsh EM, Cole D, Tipirneni KE, et al. Fluorescence Imaging of Nerves During Surgery[J]. Ann Surg, 2019, 270(1):69-76. doi: 10.1097/SLA.0000000000003130. doi: 10.1097/SLA.0000000000003130 pmid: 30649014
[21]	唐玲玲, 李力. 保留盆腔自主神经宫颈癌根治术对患者的远期疗效meta分析[J]. 现代妇产科进展, 2021, 30(11):810-814. doi: 10.13283/j.cnki.xdfckjz.2021.11.002. doi: 10.13283/j.cnki.xdfckjz.2021.11.002
[22]	He K, Li P, Zhang Z, et al. Intraoperative near-infrared fluorescence imaging can identify pelvic nerves in patients with cervical cancer in real time during radical hysterectomy[J]. Eur J Nucl Med Mol Imaging, 2022, 49(8):2929-2937. doi: 10.1007/s00259-022-05686-z. doi: 10.1007/s00259-022-05686-z URL
[23]	Jin H, Zheng L, Lu L, et al. Near-infrared intraoperative imaging of pelvic autonomic nerves: a pilot study[J]. Surg Endosc, 2022, 36(4):2349-2356. doi: 10.1007/s00464-021-08512-z. doi: 10.1007/s00464-021-08512-z URL
[24]	Lauwerends LJ, van Driel P, Baatenburg de Jong RJ, et al. Real-time fluorescence imaging in intraoperative decision making for cancer surgery[J]. Lancet Oncol, 2021, 22(5):e186-e195. doi: 10.1016/S1470-2045(20)30600-8. doi: 10.1016/S1470-2045(20)30600-8 URL
[25]	Emile SH, Khan SM, Wexner SD. Impact of change in the surgical plan based on indocyanine green fluorescence angiography on the rates of colorectal anastomotic leak: a systematic review and meta-analysis[J]. Surg Endosc, 2022, 36(4):2245-2257. doi: 10.1007/s00464-021-08973-2. doi: 10.1007/s00464-021-08973-2 URL
[26]	姚瑶, 龙颖, 卢艳, 等. ICG血管显像在保留子宫动脉输尿管分支宫颈癌根治术中的应用[J]. 肿瘤防治研究, 2019, 46(2):193-194. doi : 10.3971/j.issn.1000-8578.2019.18.0284. doi: 10.3971/j.issn.1000-8578.2019.18.0284
[27]	Escobar PF, Ramirez PT, Garcia Ocasio RE, et al. Utility of indocyanine green (ICG) intra-operative angiography to determine uterine vascular perfusion at the time of radical trachelectomy[J]. Gynecol Oncol, 2016, 143(2):357-361. doi: 10.1016/j.ygyno.2016.08.239. doi: S0090-8258(16)31262-8 pmid: 27544455
[28]	Polom J, Kalinowski L, Diana M, et al. Comprehensive Review of Fluorescence Applications in Gynecology[J]. J Clin Med, 2021, 10(19):4387. doi: 10.3390/jcm10194387. doi: 10.3390/jcm10194387 URL
[29]	Cabanes M, Boria F, Hernández Gutiérrez A, et al. Intra-operative identification of ureters using indocyanine green for gynecological oncology procedures[J]. Int J Gynecol Cancer, 2020, 30(2):278. doi: 10.1136/ijgc-2019-000895. doi: 10.1136/ijgc-2019-000895 pmid: 31722965
[30]	Kanabur P, Chai C, Taylor J. Use of Indocyanine Green for Intraoperative Ureteral Identification in Nonurologic Surgery[J]. JAMA Surg, 2020, 155(6):520-521. doi: 10.1001/jamasurg.2020.0094. doi: 10.1001/jamasurg.2020.0094 pmid: 32186665
[31]	Lee Z, Kaplan J, Giusto L, et al. Prevention of iatrogenic ureteral injuries during robotic gynecologic surgery: a review[J]. Am J Obstet Gynecol, 2016, 214(5):566-571. doi: 10.1016/j.ajog.2015.10.150. doi: 10.1016/j.ajog.2015.10.150 pmid: 26519785
[32]	彭存旭, 王云飞. 宫颈癌根治术中输尿管及膀胱保护问题[J]. 中国实用妇科与产科杂志, 2015, 31(6):519-521. doi: 10.7504/fk2015050111. doi: 10.7504/fk2015050111
[33]	Mandovra P, Kalikar V, Patankar RV. Real-Time Visualization of Ureters Using Indocyanine Green During Laparoscopic Surgeries: Can We Make Surgery Safer?[J]. Surg Innov, 2019, 26(4):464-468. doi: 10.1177/1553350619827152. doi: 10.1177/1553350619827152 pmid: 30734638
[34]	王亚婷, 李斌. 子宫颈癌前哨淋巴结活检技术的研究进展[J]. 中华肿瘤杂志, 2022, 44(5):377-381. doi: 10.3760/cma.j.cn112152-20200324-00254. doi: 10.3760/cma.j.cn112152-20200324-00254
[35]	Egloff-Juras C, Bezdetnaya L, Dolivet G, et al. NIR fluorescence-guided tumor surgery: new strategies for the use of indocyanine green[J]. Int J Nanomedicine, 2019, 14:7823-7838. doi: 10.2147/IJN.S207486. doi: 10.2147/IJN.S207486 URL
[36]	Achterberg FB, Deken MM, Meijer R, et al. Clinical translation and implementation of optical imaging agents for precision image-guided cancer surgery[J]. Eur J Nucl Med Mol Imaging, 2021, 48(2):332-339. doi: 10.1007/s00259-020-04970-0. doi: 10.1007/s00259-020-04970-0 URL