Mechanism of Traditional Chinese Medicine in Treatment of Cervical Cancer by the Intervention of Epithelial-Mesenchymal Transition

doi:10.12280/gjszjk.20250382

Abstract

Abstract:

The development and metastasis of cervical cancer are closely related to epithelial-mesenchymal transition (EMT), and traditional Chinese medicine has unique advantages in intervening in the metastasis and invasion of cervical cancer caused by EMT. To summarize the mechanism of traditional Chinese medicine intervention in the treatment of cervical cancer in recent years, it was found that the active ingredients of traditional Chinese medicine can regulate the expression of core EMT-induced transcription factors, epithelial cell markers and mesenchymal cell markers through phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), transforming growth factor-β (TGF-β), epidermal growth factor receptor (EGFR), signal transducer and activator of transcription 3 (STAT3), Wnt, Notch and other signaling pathways, so as to prevent the transition of epithelial cells to a mesenchymal phenotype. In the future, it is necessary to conduct further basic research and clinical trials to provide more references for the development of innovative traditional Chinese medicine drugs.

Key words: Uterine cervical neoplasms, Carcinoma, Epithelial-mesenchymal transition, Traditional Chinese drugs, Signal transduction, Therapy

GAO Yue, YU Jian-nan, ZHANG Li-qian, SHI Bai-chao, WANG Yu, WU Xiao-ke. Mechanism of Traditional Chinese Medicine in Treatment of Cervical Cancer by the Intervention of Epithelial-Mesenchymal Transition[J]. Journal of International Reproductive Health/Family Planning, 2026, 45(1): 77-82.

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