Abstract: Recurrent spontaneous abortion (RSA) is a common disease, but the etiology can't be fully explained. It is need to explore more deeply at molecular level. With the wide use of a series of complex proteomics techniques, many body fluids and tissues have been used in the etiological study of RSA. In this paper, the proteomic studies of different body fluids and tissues including follicular fluid, placental villi, blood and endometrium of patients with RSA in recent years were reviewed. Through comparing the characteristics of common clinical specimens one by one, we believe that plasma and endometrium are more suitable for the proteomic study of RSA etiology. This review is helpful for us to understand objectively the application of proteomics in the etiological study and early diagnosis of RSA.

Key words: Abortion, habitual, Proteomics, Follicular fluid, Placenta, Chorionic villi, Blood, Endometrium