Abstract: Obesity as an important risk factor of chronic and metabolic diseases is a global serious public health issue. Recently, it has been found that obesity can cause intergenerational transmission. With the theory of "developmental origins of health and disease", more and more studies have found that offspring obesity is closely related to maternal obesity. However, its mechanism is still not very clear. The possible mechanisms include chronic inflammatory reaction, fat tissue endocrine function, hypothalamus-adipose axis dysfunction, epigenetic changes, hereditary，gut microbial alternation and placental function changes. To clarify the relationship and the mechanisms between maternal obesity/diabetes and offspring obesity, and to block the intergenerational transmission of obesity, could lower the rate of obesity and related chronic diseases. This review describes the relationship between maternal obesity and offspring obesity and its mechanism.

Key words: Obesity；, Pregnancy；, Inflammation；, Adipose tissue；, Epigenesis, genetic；, Gastrointestinal microbiome