Abstract:

Polycystic ovary syndrome (PCOS) as a reproductive endocrine disorder is more common in the women of puberty and childbearing age, and can induce complications such as infertility, metabolic disorders and cardiovascular disease, which seriously affect the physiological and psychological health of patients. ω-3 polyunsaturated fatty acids (omega-3 PUFAs) are an important group of functional high-value fatty acids derived from vegetable oils or marine fatty fish, with anti-inflammatory, antioxidant, anti thrombotic, and lipid-lowering effects. In recent years, studies have found that supplementing with omega-3 PUFAs can improve hyperandrogenism in patients. It can also improve the metabolic status by regulating insulin resistance, obesity, and dyslipidemia in PCOS patients. In addition, omega-3 PUFAs can effectively inhibit the production of pro-inflammatory cytokines, thereby improving their chronic inflammation and oxidative stress damage status. They can also play an important role in improving the imbalance of gut microbiota in PCOS patients by increasing the abundance of healthy gut microbiota. The application of omega-3 PUFAs in the treatment of PCOS still needs further research.

Key words: Polycystic ovary syndrome, Fatty acids, omega-3, Fatty acids, unsaturated, Hyperandrogenism, Insulin resistance, Obesity, Gastrointestinal microbiome