Abstract: Objective: To analyze the difference of pregnancy outcome between pregnancy after myomectomy and pregnancy complicated by myoma. Methods：The pregnant women who underwent myomectomy in Maternal and Child Health Hospital of Anhui Medical University from October 2009 to December 2017 were selected as the postoperative pregnancy group (106 cases). Pregnant women with myoma who were delivered in this hospital in the same period were selected as the myoma-complicated pregnancy group (145 cases). Demographic data, clinical characteristics of myoma, delivery methods and pregnancy outcomes of the two groups were collected and analyzed. Results：There were no significant differences in the distribution of maternal age, household registration, educational level and previous abortion or delivery history between the two groups (all P＞0.05). There was no significant difference in the proportion of single myoma and intramural myoma between the two groups (P＞0.05). The differences in the proportion of submucosal, subserosal uterine myoma and the maximum diameter of myoma between the two groups were statistically significant (all P＜0.05). The incidences of preterm delivery and placenta previa in the postoperative pregnancy group were significantly higher than those in the myoma-complicated pregnancy group (all P＜0.05). There were no significant differences in the conception method, delivery method, abnormal presentation, fetal distress, placental accreta, premature rupture of membranes, neonatal asphyxialow, postpartum hemorrhage, postpartum blood loss in 24 hours, low birth weight and neonate birth weight between the two groups (all P＞0.05). Conclusions：Although myomectomy can improve the reproductive function in some patients, it requires a longer contraceptive time after surgery, and myomectomy has adverse effects such as increasing the incidence of preterm labor and placenta previa. Moreover, the incidence of adverse pregnancy outcomes in pregnant patients with myoma is not significantly higher than that in those pregnant patients after myomectomy. Therefore, patients with reproductive needs may consider the conservative treatment and pregnancy with myoma.

Key words:  Uterine myomectomy；, Myoma；, Pregnancy；, Pregnancy outcome；, Uterine rupture