Abstract: Objective: To compare the costs of three treatments for missed abortion, and to screen out the cost-minimization treatment. Methods：The patients diagnosed with missed abortion from January 2017 to December 2018 were divided into three groups randomly. Group A (n=513) was treated with vacuum aspiration, Group B (n=328) medical abortion with mifepristone and misoprostol, Group C (n=559) only misoprostol. Cost-minimization analysis was done. The direct medical costs were recorded and compared among 3 groups, including all tests before operation, termination of early pregnancy failure and the costs of follow-up. Results：There were no surgical complications in 3 groups. There were no significant differences in the duration of bleeding, days to onset of next menses, times and costs of follow-up among 3 groups.  The total cost of Group C was least [CNY 2 787.54 (2 474.29, 3 020.46)], and the total cost of Group A was highest [CNY 4 395.13 (4 175.16，4 627.63)]. The total cost of Group B was moderate [CNY 3 506.39 (3 151.22，3 974.91)]. There were significant differences in the groups (Z=908.950，P＜0.001). Conclusions：In those missed abortion patients without surgical complications, the medical treatment with misoprostol without mifepristone may be cheapest if only considering the medical cost.

Key words: Abortion, missed；, Cost-benefit analysis；, Mifepristone；, Misoprostol；, Vacuum aspiration