Table of Content

15 September 2020, Volume 39 Issue 5
Previous Issue    Next Issue

---

For Selected:

Download Citations EndNote Ris BibTeX

Toggle Thumbnails

Select

Screening and Bioinformatics Analysis of Sperm Differentially Expressed Proteins by Tandem Mass Spectrometry Tags Technology in Patients with Asthenozoospermia ZHANG Pan-pan, Nuerbiya Alifu, Maowulan Maimaitiyiming, MA Wen-jing, Xieraili Maimaiti, Adilijiang Yiming, Xiamixinuer Yilike, TONG Zhuo-yun 2020, 39 (5):  357-360.  Abstract ( 1451 )   PDF (3810KB) ( 9528 )   Objective: To screen the differentially-expressed proteins in sperm of patients with asthenozoospermia, to perform bioinformatics analysis, and to elucidate the important biological processes, molecular functions and related metabolic pathways, so as to provide new ideas for further mechanism research. Methods： The sperm samples were collected from 30 normal men (as the control group) and 30 asthenospermia patients, respectively. The differentially-expressed proteins in the asthenospermia group were screened and identified by tandem mass spectrometry tag technology. Bioinformatics analysis was performed by GO and KEGG. Results：With P＜0.05 and the expression ratio ≥1.2 or ≤0.833 as the standard, there were 1 020 differently-expressed proteins, including 606 upregulated proteins and 414 downregulated proteins. GO analysis showed that the differentially-expressed proteins were mainly involved in the mRNA decomposition process and the terminating translation process. They were distributed in ribosomes and cytoplasm, with binding function and receptor-activition function. The KEGG signaling pathway analysis showed that the differentially-expressed proteins were involved in 257 pathways including metabolic pathway, adenylate activated protein kinase (AMPK) signaling pathway and oxidative phosphorylation pathway. Conclusions：The Differentially-expressed proteins in patients with asthenozoospermia were involved in complex biological processes, functions and pathways. This study may provide biological information for further research on the pathogenesis of asthenozoospermia. Related Articles | Metrics

Select

Effects of Different Triggering Patterns on Oocyte Maturation and Pregnancy Outcome during Antagonist Regimen WEI Chao-feng, LIAN Fang 2020, 39 (5):  361-364.  Abstract ( 1526 )   PDF (579KB) ( 9024 )   Objective: To compare the effects of different triggering methods on the oocyte maturation and pregnancy outcome during antagonist regimen. Methods: A retrospective analysis was performed on the data of patients who underwent in vitro fertilization-embryo transfer (IVF-ET) antagonist protocol in our center from January 2014 to December 2018. A total of 176 cycles were divided into 2 groups according to the trigger method. Group A (dual trigger) was treated with gonadotropin-releasing hormone agonist (GnRHa) 0.2 mg and human chorionic-gonadotropin (hCG) 2 000 IU(n=58), and Group B (single trigger) was treated with hCG 10 000 IU, rhCG 250 μg or hCG 2 000 IU+rhCG 250 μg (n=118) . The age, infertility time, body mass index (BMI), basal follicular stimulating hormone (FSH), gonadotropin (Gn) stimulation days, Gn dosage, number of retrieved oocytes, mature oocytes rate, 2PN fertilization rate, D3I embryo rate, biochemical pregnancy rate, clinical pregnancy rate and live birth rate were analyzed. Results: There were no significant differences in the age, infertility time, BMI, basal FSH level, Gn days and Gn dosage between the two groups (P＞0.05). There were no significant differences in the mature oocytes rate, 2PN fertilization rate, biochemical pregnancy rate, ectopic pregnancy rate and abortion rate between the two groups (P＞0.05). However, the number of retrieved oocytes, D3I embryo rate , clinical pregnancy rate and live birth rate in Group A were significantly higher than those in Group B (all P＜0.05). Conclusions: Compared with hCG trigger alone in antagonist regimen, the GnRHa combined with hCG trigger method can improve the pregnancy outcome. Especially, those patients with poor oocyte and embryo quality may try the combined trigger method.  Related Articles | Metrics

Select

Effect of Intrauterine Perfusion of Autologous Peripheral Blood Mononuclear Cells on Pregnancy Outcomes in Patients with Repeated Implantation Failure：A Meta-Analysis TAN Yan, LONG Wen-xiang, ZHOU Chun-hui, LI Juan-juan, YANG Zhang-li 2020, 39 (5):  365-369.  Abstract ( 1418 )   PDF (869KB) ( 8972 )   Objective: To evaluate the effect of intrauterine autologous peripheral blood mononuclear cell (PBMC) perfusion on the pregnancy outcomes in patients with repeated implantation failure (RIF). Methods：All of the relevant literatures published in PubMed, Medline (via.OvidSP), Embase, the Cochrane Library, CNKI, WanFang Data, VIP and other major databases were retrieved electronically from their establishment to January 2020. Meta analysis was performed using RevMan 5.3 software. Results：There were 12 articles, including 5 randomized controlled trials and 7 cohort studies, were  enrolled in this Meta analysis, with a total of 1 170 RIF patients (635 received PBMC perfusion and other 535  for controls). The embryo implantation rate (RR=2.24, 95%CI: 1.42-3.54, P＜0.01), clinical pregnancy rate (RR=2.91, 95%CI: 2.21-3.87, P＜0.001) and the live birth rate (RR=2.25, 95%CI: 1.62-3.12, P＜0.001) in patients received PBMC perfusion were higher than those in the control group. However, there was no significant difference in the abortion rate between the two groups (RR=0.48, 95%CI: 0.20-1.17, P＞0.05). Conclusions：Intrauterine infusion of PBMC can improve the embryo implantation rate, clinical pregnancy rate and live birth rate of RIF patients, which is an effective measure for the treatment of RIF. Related Articles | Metrics

Select

Predictive Value of Anthropometric Indexes on Insulin Resistance in Patients with Polycystic Ovary Syndrome LIU Rui-xin, XUE Li, YAN Ya-ru, WU Hai-fei, GUO Xue-tao 2020, 39 (5):  370-373.  Abstract ( 1352 )   PDF (3011KB) ( 9067 )   Objective: To evaluate the predictive value of the four anthropometric indexes, including body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR) and waist-height ratio (WHtR), on the insulin resistance (IR) of polycystic ovary syndrome (PCOS). Methods: Retrospective analysis of 754 PCOS patients of childbearing age, receiver operating characteristic  curve (ROC), diagnostic test and binary logistic regression analysis were included in this study. Results: ①The BMI,WC,WHR，WHtR and the homeostasis model of assessment for insulin resistence index (HOMA-IR) in the PCOS with IR group were higher than those in the PCOS with non-IR group (all P＜0.05). ②The AUCs of ROC curves of BMI, WC, WHR and WHtR were 0.768, 0.769, 0.739 and 0.768. The optimal cutoff values of BMI, WC, WHR and WHtR for the prediction of IR in PCOS patients were 26.33 kg/m2, 81.15 cm, 0.85 and 0.53, respectively. ③The binary logistic regression analysis showed that BMI and WHR were risk factors of IR in PCOS patients. The risk of IR in PCOS patients with BMI≥26.33 kg/m2 was 5.189 times higher than that in PCOS patients with BMI＜26.33 kg/m2; and the risk of IR in PCOS patients with WHR≥0.85 was 1.903 times higher than that in PCOS patients with WHR＜0.85. The predictive value of BMI plus WHR was better than any one indicator (AUC of ROC curve was 0.778). Conclusions: Anthropometric indexes have predictive value for the IR of PCOS. WC or WHR can be used to predict IR in PCOS patients with abdominal obesity, and BMI can be used in PCOS patients with systemic obesity. The predictive value of BMI plus WHR is better. When BMI≥26.33 kg/m2 and/or WHR≥0.85, the risk of IR is significantly increased. The appropriate weight management in those obese PCOS patients will reduce their risk of IR. Related Articles | Metrics

Select

Cost-Minimization Analysis of Different Treatments for Missed Abortion WANG Cai-yan, QIAN Jin-feng, YAO Xiao-ying 2020, 39 (5):  374-376.  Abstract ( 1326 )   PDF (519KB) ( 8987 )   Objective: To compare the costs of three treatments for missed abortion, and to screen out the cost-minimization treatment. Methods：The patients diagnosed with missed abortion from January 2017 to December 2018 were divided into three groups randomly. Group A (n=513) was treated with vacuum aspiration, Group B (n=328) medical abortion with mifepristone and misoprostol, Group C (n=559) only misoprostol. Cost-minimization analysis was done. The direct medical costs were recorded and compared among 3 groups, including all tests before operation, termination of early pregnancy failure and the costs of follow-up. Results：There were no surgical complications in 3 groups. There were no significant differences in the duration of bleeding, days to onset of next menses, times and costs of follow-up among 3 groups.  The total cost of Group C was least [CNY 2 787.54 (2 474.29, 3 020.46)], and the total cost of Group A was highest [CNY 4 395.13 (4 175.16，4 627.63)]. The total cost of Group B was moderate [CNY 3 506.39 (3 151.22，3 974.91)]. There were significant differences in the groups (Z=908.950，P＜0.001). Conclusions：In those missed abortion patients without surgical complications, the medical treatment with misoprostol without mifepristone may be cheapest if only considering the medical cost. Related Articles | Metrics

Select

Difference of Pregnancy Outcomes between Pregnancy after Myomectomy and Pregnancy Complicated by Myoma ZHOU Yu-jia, SUN Yu-qin, JIANG Xiao-min 2020, 39 (5):  377-381.  Abstract ( 1340 )   PDF (680KB) ( 9031 )   Objective: To analyze the difference of pregnancy outcome between pregnancy after myomectomy and pregnancy complicated by myoma. Methods：The pregnant women who underwent myomectomy in Maternal and Child Health Hospital of Anhui Medical University from October 2009 to December 2017 were selected as the postoperative pregnancy group (106 cases). Pregnant women with myoma who were delivered in this hospital in the same period were selected as the myoma-complicated pregnancy group (145 cases). Demographic data, clinical characteristics of myoma, delivery methods and pregnancy outcomes of the two groups were collected and analyzed. Results：There were no significant differences in the distribution of maternal age, household registration, educational level and previous abortion or delivery history between the two groups (all P＞0.05). There was no significant difference in the proportion of single myoma and intramural myoma between the two groups (P＞0.05). The differences in the proportion of submucosal, subserosal uterine myoma and the maximum diameter of myoma between the two groups were statistically significant (all P＜0.05). The incidences of preterm delivery and placenta previa in the postoperative pregnancy group were significantly higher than those in the myoma-complicated pregnancy group (all P＜0.05). There were no significant differences in the conception method, delivery method, abnormal presentation, fetal distress, placental accreta, premature rupture of membranes, neonatal asphyxialow, postpartum hemorrhage, postpartum blood loss in 24 hours, low birth weight and neonate birth weight between the two groups (all P＞0.05). Conclusions：Although myomectomy can improve the reproductive function in some patients, it requires a longer contraceptive time after surgery, and myomectomy has adverse effects such as increasing the incidence of preterm labor and placenta previa. Moreover, the incidence of adverse pregnancy outcomes in pregnant patients with myoma is not significantly higher than that in those pregnant patients after myomectomy. Therefore, patients with reproductive needs may consider the conservative treatment and pregnancy with myoma. Related Articles | Metrics

Select

A Case Report of Unilateral Tubal Twin Gestation and Literature Review CHEN Si, CAO Lei, DENG Gao-pi 2020, 39 (5):  382-384.  Abstract ( 1168 )   PDF (4329KB) ( 9020 )   Tubal twin gestation is a kind of rare disease, and the incidence only 1/125 000. Due to the unstable hemodynamics, tubal twin gestation is more dangerous than normal ectopic pregnancy. The intraperitoneal hemorrhage of tubal twin gestation may endanger the life of pregnancy women. We reported a case of unilateral tubal twin gestation, and discussed the clinical characteristics, diagnosis and treatment with a review of literatures. Related Articles | Metrics

Select

Right Ovulation Left Tubal Pregnancy and Left Ovulation Intrauterine Pregnancy after Left Tube Resection：A Case Report and Literature Review LIU Yan, ZHANG Xiao-qin, ZHAO Zhi-mei 2020, 39 (5):  384-386.  Abstract ( 1305 )   PDF (535KB) ( 8954 )   We reported a case, the right ovarian ovulation and left fallopian tube ectopic pregnancy following the left ovarian ovulation and intrauterine pregnancy after left fallopian tube resection. This rare condition may be due to the fertilized-egg migration, the endometrial reversal movement, the offistula formation after fallopian tube resection and others. Realistically, pregnancy is a complex physiological process. In the case of monitoring follicles by B ultrasound, some rare conditions should be considered, such as the ectopic pregnancy of contralateral ovulation and the intrauterine pregnancy after tubal resection, to avoid the missed diagnosis.  Related Articles | Metrics

Select

Delayed Interval Delivery of the Twin：Three Cases Report and Literature Review LIU Guang-pu, ZHANG Hui-xin 2020, 39 (5):  387-390.  Abstract ( 1406 )   PDF (638KB) ( 8971 )   The delayed interval delivery of the twin (DIDT) refers to the extension of the delivery interval of the second fetus (F2) through conservative treatment after miscarriage or premature delivery of the first fetus (F1) in a twin pregnancy. We report three cases of DIDT from our hospital. The delivery interval of F2 was extended to varying degrees by the comprehensive treatment with anti-inflammatory, tocolytic and lung maturation promoting agents after the delivery of F1. The appropriate treatment of the delayed delivery of F2 can significantly improve the perinatal outcome of F2, which is an important measure for the F1 miscarriage or preterm delivery of twin pregnancy. For the risk of many complications in the delayed delivery of F2, both mother and relatives should be fully communicated. After weighting the advantages and disadvantages, the delayed delivery of F2 can be tried in those hospitals with the ability to treat newborns, in which the DIDT indications should be strictly mastered, the infectious index closely monitored, the complications timely found, and the termination of pregnancy be asked duly. Related Articles | Metrics

Select

Intrauterine Device Ectopia and Perforation of Uterus during Lactation: A Case Report and Literature Review WANG Li, LI Xiao, DONG Qu-long, CHEN Xiao, LIU Chuan-li 2020, 39 (5):  391-393.  Abstract ( 1318 )   PDF (1292KB) ( 8998 )   Intrauterine device (IUD) placement is a safe, effective, long-acting and reversible contraception, which is one of most commonly contraceptive methods in China. Although the complications of IUD placement are very rare, the IUD ectopia may cause serious clinical consequences. Both doctors and IUD receptors should pay enough attention to this complication. The causes of IUD ectopia could be related to the improper operation or the individual factors of receptor. We reported a case of IUD ectopia that IUD was placed during lactation. The emergency laparoscopic exploration was performed under general anesthesia. The ectopic IUD was removed, and uterine lesion was repaired by punctate electrocoagulation. After 3 days of Anti-inflammatory therapy, the patient was safely discharged from hospital. Combined with this case, the literatures on IUD ectopia were reviewed, so as to attract more attention of gynecologists and obstetricians to the high-risk factors and serious consequences of this complication of IUD placement.  Related Articles | Metrics

Select

A Case Report of Epithelioid Trophoblastic Tumor and Literatures Review SUN Pei-song, QU Peng-peng 2020, 39 (5):  394-397.  Abstract ( 1325 )   PDF (1127KB) ( 8976 )   Epithelioid trophoblastic tumor (ETT) is a rare gestational trophoblastic neoplasia (GTN), accounting for 1.39%-2% of GTN. ETT occurs mostly in women of childbearing age, especially after full-term pregnancy. The clinical manifestations are of nontypical, and the definite diagnosis is mainly based on the histopathologic examination. Surgery is the preferred option for the treatment of ETT，and the effect of chemotherapy and local radiotherapy remains controversial and individual. The factors of ETT prognosis are ambiguous, including the extra-uterinelesion  the interval over 4 years from the antecedent pregnancy. The prognosis could be better in patients without metastasis，but very poor in those patients with metastasis. Related Articles | Metrics

Select

Research Progress of Melatonin in Assisted Reproductive Technology XIE Qing-e, WANG Meng-yao, LIANG Tan, LIU Ya-jing 2020, 39 (5):  397-400.  Abstract ( 1382 )   PDF (649KB) ( 8998 )   Melatonin as a unique antioxidant, and its receptors, exist in multiple tissues or cells. Melatonin exerts a series of biological effects not only through the activation of melatonin receptors including high-affinity transmembrane receptor and nuclear receptor, but also through the unique antioxidant protection by directly removing reactive oxygen species (ROS) or by activating antioxidative enzymes. One of the key factors of assisted reproductive technology (ART) is the quality of gametes and embryos. However, the degeneration and death of oocytes and embryos are the most critical factors affecting the success rate of ART. Melatonin can not only promote the maturation of immature oocytes, improve the quality of oocytes and the development of embryos, but also protect ovarian granulosa cells and sperm after freezing and thawing. In this paper, we review the research progress of the protective effect of melatonin on oocytes, embryos, ovarian granulosa cells and sperm in ART.  Related Articles | Metrics

Select

Roles of TET3 in Regulating  Gametogenesis and Embryonic Development FU Gao-hui, YANG Tian-hao, LI Chao, BAI Yin-shan 2020, 39 (5):  401-406.  Abstract ( 1477 )   PDF (1021KB) ( 9118 )   Ten-eleven translocation 3 (TET3), one member of TET family, is a dioxygenase that depends on Fe2+ and α-ketoglutarate (α-KG). TET3 can oxidize 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) and complete the regulation of gene expression. Studies showed that the expression of TET3 was not only up-regulated during neural differentiation, but also sustained during gametogenesis, and that TET3 played an important role in regulating the early embryonic development and activation. In other words, the TET3-mediated gene expression and regulation are involved in the mammalian reproduction and embryonic development. The structure of TET3 protein, the roles of TET3 in regulating gametogenesis and embryonic development, and other TET3-related biological functions, were reviewed in this paper, so as to promote the functional research of TET3 and the application in the field of life sciences. Related Articles | Metrics

Select

Diagnosis and Treatment of Positive Antiphospholipid Antibodies in In Vitro Fertilization and Embryo Transfer Patients WU Qian-wen, MA Xiang, WANG Qiang 2020, 39 (5):  407-410.  Abstract ( 1373 )   PDF (563KB) ( 9003 )   Antiphospholipid antibody (APL) is associated with the adverse events of pregnancy closely, such as recurrent abortion, intrauterine growth restriction, preeclampsia, fetal death and premature delivery. Some scholars believe that APL is one of the reasons for the failure of in vitro fertilization and embryo transfer (IVF-ET). The failure rate of IVF and the pregnancy complications in APL-positive patients were higher than those in APL-negative patients. The frequency of IVF failure could be increased in those patients with persistent- or triple-positive APL. Up to now, there is still no consensus on the antibody testing, and prevention and management, in the APL-positive patients undergoing IVF-ET treatment. Some scholars suggest that patients undergoing IVF-ET treatment should be screened for APL, and that APL-positive patients should be treated with prophylactic anticoagulant or low-dose of aspirin (75-100 mg/d) to prevent thrombosis and to improve the clinical outcomes. However, some studies showed that the relationship between APL and IVF outcomes still lacks the support from the evidence-based medicine, and that APL screening and preventive treatment be not recommended for IVF-ET patients. In this article, we review the research progress on the diagnosis and treatment strategies of APL-positive patients undergoing IVF-ET. Related Articles | Metrics

Select

Advances in Molecular Genetics of Diminished Ovarian Reserve CHEN Hai-xia, BAI Xiao-hong 2020, 39 (5):  411-415.  Abstract ( 1330 )   PDF (668KB) ( 8995 )   Women with diminished ovarian reserve (DOR) have a normal menstrual cycle, but the decreased number and quality of oocytes and fertility decline. DOR is more often than premature ovarian failure (POF), which affects nearly 10% of patients seeking fertility treatment. However, less is known about its etiology. DOR can be divided into two groups: physiological DOR and pathological DOR. The etiology of pathological DOR may be multifactorial, including autoimmune, heredity, idiopathic and other factors. Idiopathic DOR may have genetic factors. The purpose of this article is to review the pathological DOR-related gene mutations, gene polymorphisms and telomere length, and to discuss the possible molecular screening and early diagnosis of pathological DOR through molecular genetic and etiological analysis.  Related Articles | Metrics

Select

Functions and Research Progress of Non-Coding RNA in Recurrent Implantation Failure CHEN Tong, YANG Xiao-kui 2020, 39 (5):  416-419.  Abstract ( 1241 )   PDF (509KB) ( 8963 )   Non-coding RNA (ncRNA) is a type of functional RNAs that do not directly translate into proteins, and that appear to be involved in a variety of biological processes, including epigenetic regulation, cell differentiation and proliferation, chromatin remodeling, transcriptional activation, transcriptional interference, nuclear splicing regulation, mRNA degradation, and translation regulation. Recurrent implantation failure (RIF) is a bottleneck of the success rate of in vitro fertilization and embryo transfer (IVF-ET), therefore a research hotspot in reproductive medicine. In recent years, accumulating evidence has shown that the abnormal expressions of microRNA (miRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA) in the endometrium, oocytes and cumulus cells could lead to RIF by impairing the endometrial receptivity, synchronous development of embryo and endometrium and embryo quality. This article reviews the function and research progress of ncRNA related to recurrent implantation failure. Related Articles | Metrics

Select

Research Progress of Non-Coding RNAs in Ovarian Aging BAI Lin, YANG Xiao-kui 2020, 39 (5):  420-425.  Abstract ( 1220 )   PDF (816KB) ( 9011 )   Ovarian aging refers to the process of gradual decline of ovarian reserve before ovarian failure. The decreasing numbers of follicles and diminished oocyte quality are the main manifestations of ovarian aging, which reduces the ovarian endocrine function and female fertility. The impaired follicular development and accelerated follicle atresia lead to a decrease in the number of follicles, while the decline of oocyte quality is related to the disorder of DNA damage-repair, oxidative stress and the dysfunction of mitochondria. Although the mechanism of ovarian aging is still unclear, recent studies have found that non-coding RNAs (ncRNA) as a group of functional RNA molecules participate in the regulation of ovarian function, especially in the differentiation, proliferation and apoptosis of ovarian cells. NcRNAs participate in the occurrence of ovarian aging by affecting follicular development and atresia, the synthesis and secretion of ovarian hormones. With the development of science and technology, more and more mechanisms of ncRNA in regulating ovarian aging will be discovered, providing new ideas for the diagnosis and treatment of ovarian aging. This review focuses on the research progress of ncRNAs in ovarian aging. Related Articles | Metrics

Select

Progress of MiRNAs in the Regulation of Reproductive Endocrine Diseases WEN Xin, ZHANG Yang, ZHANG Yue-hui, YAO Mei-yu 2020, 39 (5):  425-431.  Abstract ( 1186 )   PDF (1017KB) ( 9087 )    Reproductive endocrine diseases are a kind of diseases related with reproductive health. The etiology and clinical features of these diseases were highly heterogeneous. MicroRNAs (miRNAs) are a kind of single-stranded small RNAs composed of 19-24 nucleotides. They can promote the degradation of mRNAs or inhibit the translation of proteins by binding to target mRNAs. As a post-transcriptional regulator of gene expression, miRNAs play an important regulatory role in the whole life process. Recently, with the development of transcriptome sequencing, more and more results have identified the important effects of miRNAs on the pathological mechanism of premature ovarian insufficiency (POI), polycystic ovary syndrome (PCOS) and many other reproduction-related diseases. In this paper, we discuss the regulatory mechanism of miRNAs in reproductive diseases and the potential biomarkers. Related Articles | Metrics

Select

Research Progress on the Relationship between Long Non-Coding RNA and Polycystic Ovary Syndrome XU Xiao-hu, ZHENG Cui-hong, ZHOU Li-shan 2020, 39 (5):  432-436.  Abstract ( 1338 )   PDF (665KB) ( 9003 )   Polycystic ovary syndrome (PCOS) is a common clinical reproductive endocrine disease, and the incidence increases year by year. The pathogenesis of PCOS is related to many factors, in which the genetic factor may play a key role. Long non-coding RNA (lncRNA) refers to a kind of RNAs whose length exceeds 200 nucleotides. Although lncRNAs do not participate in the translation of protein, the activites of lncRNAs and the changes of activities are closely related to the growth and development, cell proliferation, differentiation and apoptosis. More and more studies have shown that lncRNAs are related to the pathogenesis of PCOS. lncRNAs may play some roles in the sex hormone secretion, insulin resistance, follicular development, granulosa cell proliferation and apoptosis, suggesting that lncRNAs almost participate in all aspects of PCOS development. This article reviews the recent research progress of lncRNAs in the pathogenesis of PCOS, to provide new ideas for the diagnosis and treatment of PCOS. Related Articles | Metrics

Select

Expression Patterns of Long Non-Coding RNAs in Ovarian Cancer and Possible Application HE Zheng-qin, ZHANG Guang-mei 2020, 39 (5):  437-440.  Abstract ( 1211 )   PDF (543KB) ( 8957 )   Ovarian cancer is one of the most lethal gynecological cancers. The development of useful biomarkers for the diagnosis and prognosis of ovarian cancer is essential for new targeted therapies and prolonging the survival time. Long non-coding RNAs (lncRNAs) , a kind of non-coding transcripts which have been emerging recently, are involved in the occurrence and development of various diseases. Some LncRNAs have been proved to play a key functional role in ovarian cancer, which is the basis of targeted therapy of individualized drugs. In this article, the basic structure, function, localization and classification of lncRNAs, as well as the research methods, were summarized, and the relationship between the different expression patterns of lncRNAs in ovarian cancer and the proliferation, differentiation, invasion and treatment response of ovarian cancer cells was expounded. In addition, the potential value of lncRNAs as a therapeutic target for ovarian cancer, so as to improve chemotherapy resistance, was also discussed. Related Articles | Metrics