Abstract: Endometrium undergoes proliferation, secretion and scaling, or decidualization for embryo implantation, in women of reproductive age. Endometrium injury induced by innate causes, artificial factors or disease leads to intrauterine adhesion (IUA) and thin endometrium, which resulting in female infertility. Limited therapeutic options can offer for these patients, with unsatisfactory therapeutic effect. As a novel mean of treatment, stem cell therapies bring a new hope to these patients. Many clinical studies showed that autologous stem cell therapies could improve endometrium thickness and clinical pregnancy rate of the patients with IUA. This review offers a summary of clinical and experimental evidence of stem cell-based therapy in IUA and thin endometrium. The safety of stem cell therapies, and autologous or allosome origin of stem cell, are two crucial issues of stem cell-based therapy in the present clinical practice.

Key words: Stem cells；, Uterine diseases；, Tissue adhesions；, Endometrium；, Infertility, female；, Animal experimentation；, Therapy