Abstract: Objective： To develop a management information system（ＭＩＳ） which can be used in the clinical service and aetiological study of congenital heart defects（ＣＨＤ）. Methods： Healthy pregnant women and those who conceived CHD fetus were recruited in this study, and followed up till childbirth. Maternal exposures during pregnancy were obtained using questionnaire survey. Biospecimens of mothers and infants were also collected. The functions of MIS were defined based on the needs of clinical services and aetiological researches. Caché database technology was adopted to construct database, and the Microsoft. NET platform was used to develop program modules. Results： A multi?鄄layered browser/server system with functions of online data quering, analyzing and managing has been built to process data from different sources including questionnaire, clinical tests and biospecimens. Conclusions： Due to the integration of clinical and research data, this platform can improve the pool analysis of data from multiple sources, which benefits to the multicenter studies on the etiology of CHD.

Key words: Heart defects, congenital, Management information systems, Database management systems, Physician’s practice patterns, Multicenter study, Information storage and retrieval