Adipokines and Gestational Diabetes Mellitus and Glucose Lipid Metabolism

doi:10.12280/gjszjk.20200617

Abstract

Abstract:

Gestational diabetes mellitus (GDM) is one of the major complications during pregnancy. With the implementation of the two-child policy, the improvement of living standard and the change of marriage concept, the incidence of GDM has been increasing year by year under the influence of high risk factors such as obesity, age and genetic susceptibility. At present, the specific pathogenesis of GDM is not clear, which may be related to insulin resistance and dysfunction of insulin β cell. The disorder of glucose metabolism in pregnant women with GDM will further lead to the disorder of lipid metabolism, leading to adverse pregnant outcomes. Adipokines, such as betatrophin, chemerin, C1q/tumor necrosis factor related protein (CTRP9) and leptin, may play a role in the pathogenesis of GDM. This article reviews the roles of adipokines in the regulation of glucose and lipid metabolism, and the pathogenesis of GDM.

Key words: Diabetes, gestational, Insulin resistance, Adipokines, Glucose metabolism disorders, Leptin, Lipid metabolism

ZHENG Kai, YUAN Jing. Adipokines and Gestational Diabetes Mellitus and Glucose Lipid Metabolism[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(5): 431-435.

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