Abstract:

The metabolic abnormality with hyperandrogenemia, insulin resistance and obesity in patients with polycystic ovary syndrome (PCOS) has been a hot topic of study and clinical treatment of PCOS. A complex community of microorganisms resides within the intestine. Gut microbiome and the host life-long companion are the relationship of the mutual benefit symbiosis. In recent years, the correlation between gut microbiome and tumors, immunity, metabolic disease has become a hot topic. Meanwhile, there are increasing literatures on the correlation between gut microbiome and the metabolic abnormality of PCOS patients. Many studies have showed that there are positive correlations between gut microbiome and insulin resistance, hyperandrogenism, chronic inflammation and metabolic syndrome, and that gut microbiome may contribute to the development of clinical features of PCOS by the pathways of short chain fatty acids, lipopolysaccharides, sex hormone levels and the brain-gut axis. In addition, there were also a few clinical studies that the fecal microbiota transplantation, supplementation with probiotics and traditional Chinese medicine were tried to regulate gut microbiome in a small sample test so as to treat some disorders.

Key words: Polycystic ovary syndrome, Gut microbiome, Metabolism, Insulin resistance, Therapy