Effect of Vitamin D on Outcomes of Assisted Reproduction Technology

doi:10.12280/gjszjk.20210609

Abstract

Abstract:

Vitamin D not only participates in the calcium and phosphorus metabolism and the skeletal homeostasis as a steroid hormone, but also plays a role as a reproductive hormone. In women, vitamin D is involved in follicular formation and the production of ovarian sex hormones, which affects ovarian reserve function. In men, it can affect semen quality and sperm motility. Vitamin D receptor is widely expressed in the reproductive organs of both sexes, which can affect the fertility and pregnancy outcome of assisted reproductive technology through a variety of mechanisms. However, there is no consensus on whether exogenous vitamin D supplementation improves pregnancy outcomes of infertile patients undergoing assisted reproductive technology. This paper reviews the effect of vitamin D on male and female reproductive function, and discusses whether vitamin D can improve the outcome of assisted reproductive technology.

Key words: Vitamin D, Fertility, Reproductive techniques, assisted, Pregnancy outcome, Ovarian reserve

WANG Qing-di, XIONG Zheng-fang. Effect of Vitamin D on Outcomes of Assisted Reproduction Technology[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(2): 143-146.

References 31

[1]	Holick MF. Vitamin D deficiency[J]. N Engl J Med, 2007, 357(3):266-281. doi: 10.1056/NEJMra070553. doi: 10.1056/NEJMra070553 URL
[2]	Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation,treatment,and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline[J]. J Clin Endocrinol Metab, 2011, 96(7):1911-1930. doi: 10.1210/jc.2011-0385. doi: 10.1210/jc.2011-0385 URL
[3]	Shahrokhi SZ, Ghaffari F, Kazerouni F. Role of vitamin D in female reproduction[J]. Clin Chim Acta, 2016, 455:33-38. doi: 10.1016/j.cca.2015.12.040. doi: 10.1016/j.cca.2015.12.040 pmid: 26747961
[4]	Blomberg Jensen M, Nielsen JE, Jørgensen A, et al. Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract[J]. Hum Reprod, 2010, 25(5):1303-1311. doi: 10.1093/humrep/deq024. doi: 10.1093/humrep/deq024 URL
[5]	Yao X, Wang Z, El-Samahy MA, et al. Roles of vitamin D and its receptor in the proliferation and apoptosis of luteinised granulosa cells in the goat[J]. Reprod Fertil Dev, 2020, 32(3):335-348. doi: 10.1071/RD18442. doi: 10.1071/RD18442 URL
[6]	Merhi Z, Doswell A, Krebs K, et al. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells[J]. J Clin Endocrinol Metab, 2014, 99(6):E1137-E1145. doi: 10.1210/jc.2013-4161. doi: 10.1210/jc.2013-4161 URL
[7]	Arefi S, Khalili G, Iranmanesh H, et al. Is the ovarian reserve influenced by vitamin D deficiency and the dress code in an infertile Iranian population?[J]. J Ovarian Res, 2018, 11(1):62. doi: 10.1186/s13048-018-0435-7. doi: 10.1186/s13048-018-0435-7 URL
[8]	Naderi Z, Kashanian M, Chenari L, et al. Evaluating the effects of administration of 25-hydroxyvitamin D supplement on serum anti-mullerian hormone (AMH) levels in infertile women[J]. Gynecol Endocrinol, 2018, 34(5):409-412. doi: 10.1080/09513590.2017. 1410785. doi: 10.1080/09513590.2017.1410785 pmid: 29212401
[9]	李施施, 张岭, 姬萌霞, 等. 卵巢储备功能评估指标与维生素D的相关性分析[J]. 预防医学, 2020, 32(8):828-831. doi: 10.19485/j.cnki.issn2096-5087.2020.08.017. doi: 10.19485/j.cnki.issn2096-5087.2020.08.017
[10]	Drakopoulos P, van de Vijver A, Schutyser V, et al. The effect of serum vitamin D levels on ovarian reserve markers: a prospective cross-sectional study[J]. Hum Reprod, 2017, 32(1):208-214. doi: 10.1093/humrep/dew304. doi: 10.1093/humrep/dew304
[11]	Karimi E, Arab A, Rafiee M, et al. A systematic review and meta-analysis of the association between vitamin D and ovarian reserve[J]. Sci Rep, 2021, 11(1):16005. doi: 10.1038/s41598-021-95481-x. doi: 10.1038/s41598-021-95481-x URL
[12]	Reginatto MW, Pizarro BM, Antunes RA, et al. Vitamin D receptor taqi polymorphism is associated with reduced follicle number in women utilizing assisted reproductive technologies[J]. Front Endocrinol (Lausanne), 2018, 9:252. doi: 10.3389/fendo.2018.00252. doi: 10.3389/fendo.2018.00252 URL
[13]	Malloy PJ, Peng L, Wang J, et al. Interaction of the vitamin D receptor with a vitamin D response element in the Mullerian-inhibiting substance (MIS) promoter: regulation of MIS expression by calcitriol in prostate cancer cells[J]. Endocrinology, 2009, 150(4):1580-1587. doi: 10.1210/en.2008-1555. doi: 10.1210/en.2008-1555 pmid: 19056816
[14]	Walz NL, Hinchliffe PM, Soares MJ, et al. Serum Vitamin D status is associated with increased blastocyst development rate in women undergoing IVF[J]. Reprod BioMed Online, 2020, 41(6):1101-1111. doi: 10.1016/j.rbmo.2020.08.014. doi: 10.1016/j.rbmo.2020.08.014 URL
[15]	Hosseinirad H, Novin MG, Hosseini S, et al. Effect of 1, 25(OH)₂-vitamin D3 on expression and phosphorylation of progesterone receptor in cultured endometrial stromal cells of patients with repeated implantation failure[J]. Acta Histochem, 2020, 122(2):151489. doi: 10.1016/j.acthis.2019.151489. doi: S0065-1281(19)30479-9 pmid: 31879032
[16]	Fabris AM, Cruz M, Iglesias C, et al. Impact of vitamin D levels on ovarian reserve and ovarian response to ovarian stimulation in oocyte donors[J]. Reprod Biomed Online, 2017, 35(2):139-144. doi: 10.1016/j.rbmo.2017.05.009. doi: 10.1016/j.rbmo.2017.05.009 URL
[17]	Ikemoto Y, Kuroda K, Nakagawa K, et al. Vitamin D regulates maternal T-helper cytokine production in infertile women[J]. Nutrients, 2018, 10(7):902. doi: 10.3390/nu10070902. doi: 10.3390/nu10070902 URL
[18]	Chen W, Jiao X, Zhang J, et al. Vitamin D deficiency and high serum IL-6 concentration as risk factors for tubal factor infertility in Chinese women[J]. Nutrition, 2018, 49:24-31. doi: 10.1016/j.nut.2017.11.016. doi: 10.1016/j.nut.2017.11.016 URL
[19]	Aramesh S, Alifarja T, Jannesar R, et al. Does vitamin D supplementation improve ovarian reserve in women with diminished ovarian reserve and vitamin D deficiency: a before-and-after intervention study[J]. BMC Endocri ne Disord, 2021, 21(1):126. doi: 10.1186/s12902-021-00786-7. doi: 10.1186/s12902-021-00786-7
[20]	He J, Wang H, Shi J, et al. 1, 25-Dihydroxyvitamin D deficiency accelerates male reproductive senescence in aging mice and 1, 25 (OH) 2D3 alleviates oxidative stress via NF-κB/SOD[J]. Am J Physiol Endocrinol Metab, 2021, 320(4):E732-E746. doi: 10.1152/ajpendo.00531.2020. doi: 10.1152/ajpendo.00531.2020 URL
[21]	Rehman R, Lalani S, Baig M, et al. Association between vitamin D, reproductive hormones and sperm parameters in infertile male subjects[J]. Front Endocrinol(Lausanne), 2018, 9:607. doi: 10.3389/fendo.2018.00607. doi: 10.3389/fendo.2018.00607
[22]	Jueraitetibaike K, Ding Z, Wang DD, et al. The effect of vitamin D on sperm motility and the underlying mechanism[J]. Asian J Androl, 2019, 21(4):400-407. doi: 10.4103/aja.aja_105_18. doi: 10.4103/aja.aja_105_18 pmid: 30618415
[23]	Bøllehuus Hansen L, Rehfeld A, de Neergaard R, et al. Selection of high-quality spermatozoa may be promoted by activated vitamin D in the woman[J]. J Clin Endocrinol Metab, 2017, 102(3):950-961. doi: 10.1210/jc.2016-3008. doi: 10.1210/jc.2016-3008 pmid: 27977320
[24]	Blomberg Jensen M, Lawaetz JG, Petersen JH, et al. Effects of vitamin D supplementation on semen quality,reproductive hormones,and live birth rate: a randomized clinical trial[J]. J Clin Endocrinol Metab, 2018, 103(3):870-881. doi: 10.1210/jc.2017-01656. doi: 10.1210/jc.2017-01656 pmid: 29126319
[25]	Banks N, Sun F, Krawetz SA, et al. Male vitamin D status and male factor infertility[J]. Fertil Steril, 2021, 116(4):973-979. doi: 10.1016/j.fertnstert.2021.06.035. doi: 10.1016/j.fertnstert.2021.06.035 URL
[26]	Cozzolino M, Busnelli A, Pellegrini L, et al. How vitamin D level influences in vitro fertilization outcomes: results of a systematic review and meta-analysis[J]. Fertil Steril, 2020, 114(5):1014-1025. doi: 10.1016/j.fertnstert.2020.05.040. doi: 10.1016/j.fertnstert.2020.05.040 pmid: 33012554
[27]	Somigliana E, Sarais V, Reschini M, et al. Single oral dose of vitamin D3 supplementation prior to in vitro fertilization and embryo transfer in normal weight women: the SUNDRO randomized controlled trial[J]. Am J Obstet Gynecol, 2021, 225(3):283.e1-283.e10. doi: 10.1016/j.ajog.2021.04.234. doi: 10.1016/j.ajog.2021.04.234
[28]	Jiang L, Ji L, Song J, et al. The effect of serum vitamin D levels in couples on embryo development and clinical outcomes[J]. Reprod Biomed Online, 2019, 38(5):699-710. doi: 10.1016/j.rbmo.2018. 12.036. doi: S1472-6483(18)30665-5 pmid: 30772193
[29]	Liu X, Zhang W, Xu Y, et al. Effect of vitamin D status on normal fertilization rate following in vitro fertilization[J]. Reprod Biol Endocrinol, 2019, 17(1):59. doi: 10.1186/s12958-019-0500-0. doi: 10.1186/s12958-019-0500-0 URL
[30]	Wu L, Kwak-Kim J, Zhang R, et al. Vitamin D level affects IVF outcome partially mediated via Th/Tc cell ratio[J]. Am J Reprod Immunol, 2018, 80(6):e13050. doi: 10.1111/aji.13050. doi: 10.1111/aji.13050 URL
[31]	Muyayalo KP, Song S, Zhai H, et al. Low vitamin D levels in follicular fluid, but not in serum, are associated with adverse outcomes in assisted reproduction[J]. Arch Gynecol Obstet, 2021 Aug 8. doi: 10.1007/s00404-021-06174-9. Epub ahead of print. doi: 10.1007/s00404-021-06174-9