The Relationship between BMI, Serum Albumin and Iron Metabolism in Pregnant Women with Mild Thalassemia

doi:10.12280/gjszjk.20220272

Abstract

Abstract:

Objective: To observe the changes of the nutritional status calibrated by BMI and serum albumin in early-pregnant women with mild thalassemia, and iron metabolism levels, and to explore the relationship between nutritional status and iron metabolism in these pregnant women. Methods: The levels of serum iron (SI), serum ferritin (SF) and hemoglobin (Hb) in 634 pregnant women with mild thalassemia, from October 2018 to October 2020, were retrospectively analyzed. According to the nutritional status, the pregnant women were divided into the low weight-malnutrition group (group A), the low weight-good nutrition group (group B), the high weight-malnutrition group (group C) and the high weight-good nutrition group (group D). Results: With the increase of gestational age, the levels of SI, SF and Hb of pregnant women in the four groups showed a downward trend. The levels of SF and SI in group D were lower than those in other three groups at different gestational periods (all P<0.05). The levels of SF in group A were higher than those in the other three groups in the middle and late pregnancy, the levels of SI were higher than those in the other three groups at different gestational periods, while the levels of Hb were lower than those in the other three groups at different gestational periods (all P<0.05). Conclusions: Pregnant women with mild thalassemia, especially those with low weight- malnutrition and high weight-good nutrition, may have iron deficiency anemia. Therefore, it is necessary to dynamically monitor the level of iron metabolism during the pregnancy of mild thalassemia, and those with high iron load or good nutritional status in the early pregnancy should not be ignored. Nutrition or iron supplementation should be given to different individuals to reduce the risk of iron deficiency anemia.

Key words: Thalassemia, Pregnant women, Iron metabolism disorders, Nutritional status, Pregnancy trimester, first, Pregnancy trimester, second, Pregnancy trimester, third

PENG Jing, LAO Shao-xing, SONG Peng-shu, WEI Hong-wei, YANG Juan-juan, YANG Qin-ling. The Relationship between BMI, Serum Albumin and Iron Metabolism in Pregnant Women with Mild Thalassemia[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(2): 107-110.

Figures/Tables 3

References 19

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营养状态	n	妊娠早期	妊娠中期	妊娠晚期
A组	86	185.49±48.48	75.85±35.94^a	57.45±28.89^ab
B组	207	178.06±46.06	46.80±21.80^Aa	35.41±16.39^Aab
C组	92	178.95±31.71	37.51±13.02^ABa	32.95±13.18^Aa
D组	249	105.44±12.96^ABC	29.90±13.17^ABCa	16.24±6.96^ABCab
F_营养状态			426.13**
F_妊娠时期			4 410.99**
F_交互			79.28**

营养状态	n	妊娠早期	妊娠中期	妊娠晚期
A组	86	185.49±48.48	75.85±35.94^a	57.45±28.89^ab
B组	207	178.06±46.06	46.80±21.80^Aa	35.41±16.39^Aab
C组	92	178.95±31.71	37.51±13.02^ABa	32.95±13.18^Aa
D组	249	105.44±12.96^ABC	29.90±13.17^ABCa	16.24±6.96^ABCab
F_营养状态			426.13**
F_妊娠时期			4 410.99**
F_交互			79.28**

营养状态	n	妊娠早期	妊娠中期	妊娠晚期
A组	86	18.00±1.26	16.07±1.26^a	14.98±1.13^ab
B组	207	17.05±1.16^A	14.95±1.21^Aa	14.60±2.02^Aab
C组	92	17.01±1.15^A	14.99±1.20^Aa	13.73±1.11^ABab
D组	249	11.10±1.13^ABC	10.92±1.13^ABCa	11.50±0.87^ABC
F_营养状态			1 952.90**
F_妊娠时期			273.91**
F_交互			85.37**

营养状态	n	妊娠早期	妊娠中期	妊娠晚期
A组	86	18.00±1.26	16.07±1.26^a	14.98±1.13^ab
B组	207	17.05±1.16^A	14.95±1.21^Aa	14.60±2.02^Aab
C组	92	17.01±1.15^A	14.99±1.20^Aa	13.73±1.11^ABab
D组	249	11.10±1.13^ABC	10.92±1.13^ABCa	11.50±0.87^ABC
F_营养状态			1 952.90**
F_妊娠时期			273.91**
F_交互			85.37**

营养状态	n	妊娠早期	妊娠中期	妊娠晚期
A组	86	103.72±3.15	100.92±3.00^a	99.58±2.55^ab
B组	207	105.97±2.76^A	104.99±3.24^Aa	100.65±3.31^Aab
C组	92	105.44±2.89^A	102.57±3.35^ABa	101.84±3.03^ABa
D组	249	107.33±3.13^ABC	107.32±3.20^ABCa	106.46±2.61^ABCab
F_营养状态			283.72**
F_妊娠时期			176.96**
F_交互			29.35**