Research Progress of Ferroptosis in Obstetric Diseases

doi:10.12280/gjszjk.20230197

Abstract

Abstract:

Ferroptosis is a new type of programmed cell death. The main pathological feature of ferroptosis is the accumulation of free iron and lipid peroxidation products, which mainly involves iron metabolism, amino acid metabolism and lipid metabolism. Recent studies have shown that ferroptosis leads to trophoblastic injury and placental dysfunction through various ways such as affecting cellular lipid metabolism and oxidative stress, and that ferroptosis plays an important regulatory role in the occurrence and development of obstetric diseases such as pre-eclampsia, gestational diabetes mellitus, spontaneous preterm birth, abortion and fetal growth restriction. In this paper, we reviewed the mechanism of ferroptosis and its correlation with obstetric diseases, so as to provide new ideas for further study of the pathogenesis and treatment of obstetric diseases.

Key words: Ferroptosis, Iron metabolism disorders, Oxidative stress, Pre-eclampsia, Diabetes, gestational, Abortion, spontaneous, Premature birth, Fetal growth retardation

HE Yue, CUI Hong-mei. Research Progress of Ferroptosis in Obstetric Diseases[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(5): 414-418.

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