Research Progress of the Controlled Ovarian Stimulation Protocols for Women with Endometriosis-Related Infertility

doi:10.12280/gjszjk.20230158

Abstract

Abstract:

In vitro fertilization-embryo transfer (IVF-ET) is an effective method for the treatment of infertility combined with endometriosis (EMs). The ultra-long protocol of gonadotropin-releasing hormone agonist (GnRHa) for the long-term down-regulation of pituitary can help to improve pregnancy outcomes in infertile patients with EMs. In recent years, more and more ovulation induction protocols have been applied in patients with EMs-related infertility, such as gonadotropin-releasing hormone antagonist (GnRH_A) protocol and progestin-primed ovarian stimulation (PPOS) protocol. These protocols have showed their potential in improving the pregnancy outcomes in patients with EMs-related infertility. However, the choice of ovulation induction protocols in patients with EMs-related infertility is controversial due to unknown etiology, complex staging and clinical heterogeneity. It is necessary to conduct more high-quality clinical studies to validate the efficiency of these protocols in the different individuals.

Key words: Endometriosis, Controlled ovarian stimulation, Ovulation induction, Fertilization in vitro, Embryo transfer, Gonadotropin-releasing hormone, GnRH-agonist long protocol, GnRH-antagonist protocol, Progestin-primed ovarian stimulation protocol, Pregnancy outcome

CHEN Yin, WANG Jing, MAO Yun-dong. Research Progress of the Controlled Ovarian Stimulation Protocols for Women with Endometriosis-Related Infertility[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(5): 398-402.

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