Abstract:

Small cell neuroendocrine carcinoma of the cervix (SCNCC) is prone to lymphatic metastasis in the early stage, unique pathological manifestations, easy to recur, and poor prognosis. Data from one case of SCNCC (stage ⅢC1r) is reported. The patient presented with intermittent vaginal bleeding with lower abdominal pain for more than 1 month. Combined with the results of pelvic magnetic resonanace imaging (MRI), total abdominal CT and hysteroscopy with endometrial biopsy, it was diagnosed as SCNCC at ⅢC1r stage. According to the 2022 National Comprehensive Cancer Network (NCCN) guidelines, the patient was given 3 cycles of neoadjuvant chemotherapy (carboplatin plus etoposide neoadjuvant), followed by laparoscopic extensive hysterectomy plus bilateral oophorectomy plus bilateral salpingectomy plus pelvic lymph node dissection plus abdominal para-aortic lymphadenectomy plus antitumor drug intraperitoneal perfusion therapy (nidaplatin flushing the abdominal cavity) plus bilateral ureteral stent implantation. After surgery, the patient was given 3 cycles of chemotherapy again. No recurrence was seen in 13 months of postoperative follow-up.

Key words: Carcinoma, neuroendocrine, Carcinoma, small cell, Uterine cervical neoplasms, Image-guided biopsy, Case reports