The Role of CircRNAs in Follicular Granulosa Cells of Patients with Endometriosis Infertility

doi:10.12280/gjszjk.20230529

Abstract

Abstract:

The abnormal follicular development is one of the pathological mechanisms of infertility in patients with endometriosis (EMs). In recent years, the role of circular RNA (circRNA) in the development of endometrium-related diseases has attracted more attention. However, the research on the role of circRNAs in EMs is still at the early stage, and the role of circRNA in the development of EMs follicles is especially unclear. It is currently known that circRNAs can participate in the occurrence and development of EMs by affecting the proliferation and apoptosis of granulosa cells, epithelial-mesenchymal transition, microenvironment of follicular fluid and hormone regulation, which further lead to infertility. This review aims to elucidate the research progress on the potential impact of circRNAs on follicular granulosa cells leading to adverse pregnancy outcomes, and to explore the possibility of circRNAs as a biomarker for EMs, so as to provide new ideas and methods for clinical diagnosis and treatment.

Key words: Endometriosis, Infertility, female, RNA, circular, Ovarian follicle, Granulosa cells

GAO Zhao-yang, ZHANG Ning-qing, CHEN Qiong-hua, WU Rong-feng. The Role of CircRNAs in Follicular Granulosa Cells of Patients with Endometriosis Infertility[J]. Journal of International Reproductive Health/Family Planning, 2024, 43(3): 243-248.

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