Research Progress on the Correlation between the Endometrial Cancer Associated with Type 2 Diabetes Mellitus and the Intestinal Flora

doi:10.12280/gjszjk.20240034

Abstract

Abstract:

Type 2 diabetes mellitus (T2DM) is related to the higher incidence and the increased invasiveness of endometrial cancer (EC). Hyperglycemia, hyperinsulinemia, insulin resistance and obesity in patients with T2DM have been widely studied as potential pathogenesis of EC, and the imbalance of intestinal flora may be the key factor of T2DM-related EC. This paper summarizes the relationships between T2DM and EC, T2DM and intestinal flora, T2DM-related EC and intestinal flora, including the abnormal expression of microRNA, mitochondrial dysfunction, inflammation and adiponectin level, and the progress of intestinal flora in treating T2DM-related EC, in order to provide a reference for the prevention and treatment of T2DM-related EC from the perspective of intestinal flora.

Key words: Gastrointestinal microbiome, Diabetes mellitus, type 2, Endometrial neoplasms, Therapy

WANG Fang, WAN Tao, YANG Yong-xiu. Research Progress on the Correlation between the Endometrial Cancer Associated with Type 2 Diabetes Mellitus and the Intestinal Flora[J]. Journal of International Reproductive Health/Family Planning, 2024, 43(3): 249-253.

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