Abstract: The concept of reproductive security was firstly suggested in 2005 by the inaugural meeting of the China Medical Association Reproductive Medicine Branch. So far，the reproductive security received unprecedented attention. The new concept of embryo origin of adult diseases has been explored in the national kebasic research program’The mechanism of embryo origin of adult disease caused by assisted reproductive technology ‘. Those non -physiological process involved in assisted reproductive technology （ART），includingsuperovulation，in vitro fertilization，in vitro culture，gamete/embryo freezing and thawing，blastomere biopsy，cause the problem of reproductive security. ART may related to the high rates of miscarriage，premature birth，congenital malformations，low birth body mass and other adverse health risks，genetic diseases，chromosomal abnormalities，abnormal epigenetic modifications，nervous system abnormalities，cardiovascular disease and metabolic disorders in adulthood. Besides ART itself，those parental reproductive disorders might influence gametogenesis，fertilization，embryo development，and implantation. The adverse intrauterine environment caused by parental pregnanccomplications might related to the occurrence of the delayed adult disease in offspring interfereing the gene andprotein expression. Parental infectious diseases possibly might vertically transmit to offspring by gametes，which significantly affect the health of offspring. The reproductive security also depends on environmental safety. Theharmful physical and chemical factors in environment might have an adverse impact on the reproductive behavior.

Key words: Reproductive technology, assisted, Sperm injections, intracytoplasmic, Fertilization in vitro, Embryo transfer