Abstract: Homeobox Gene HOXA10, one member of the multi -gene family of transcriptional regulation, plays an important role in determining endometrial receptivity. HOXA10 is mainly involved in regulation of embryo implantation and endometrial decidualization. The mechanism may be related to endothelin type A receptor, Kruppel-like factor 9, GABA（A）pi recepto, 3-phosphoglycerate dehydrogenasecalpain, cigarett smoke, p300/CBP-associated factor, tryptoph an 2, 3-dioxygenase. Integrin茁3 and Emx2 are downstream genes of HOXA10 in endometrial cells. HOXA10 inhibites expression of Emx2, but activates integrin茁3,which play an important role in embryo implantation and decidualization of stromal cells. The abnormal regulation of HOXA10 expression causes infertility.

Key words: Homeodomain proteins, Gene expression regulation, Genes, homeobox, Integrin beta3, Infertility, female, Endometrium