Abstract: The poor ovarian response, a problem of controlled ovarian hyperstimulation in IVF-ET, ischaracteristic of the poor outcome of ovarian hyperstimulation failure, the limited number of recruit follicles, andlowerE2 level, which often leads to the cycle cancel of IVF-ET. The incidence of poor response in IVF-ET is9% to 24% . The mechanism of poor ovarian response is not well clarified; even the diagnosis standard isskimble-scamble. Various treatment protocols were proposed to improve the ovarian reactivity of patients withthe poor ovarian response. These protocols were listed as follows：淤Increasing the stimulation dose of rFSH. 于Pituitary down regulation. 盂The use of androgens or androgen-modulating agents. 榆Administration of growth hormone. 虞Modified natural cycle IVF. 愚Adjuvant therapy such as the use of oral contraceptive pill（COCP），E2. There is little understanding which one is the best protocol to treat effectively the poor ovarian response. Itcould be a feasible choice for different individual to havea suitable and personalized protocol.

Key words: Fertilization in Vitro, Embryo transfer, Reproductive techniques, assisted, Ovarian failure, premature