Abstract: Polycystic ovary syndrome（PCOS） is the major cause of ovulation failure induced infertility， which is characterized by continuous ovulation obstacles，hyperandrogenemia and insulin resistance. The prevalence of PCOS is approximately 5%~10%. The etiology and pathogenesis of PCOS are still unknown. With the technique development，especially the emergence of high throughout sequence platform，research on PCOS has been revolutionized. We reviewed the progress of PCOS， including heredity， predisposing genes，environmental and psychologic factors，and metabolic syndrome.

Key words: Polycystic ovary syndrome, Metabolic syndrome, Infertility, female, Genes