Abstract: Anti-Müllerian hormone（AMH）， a member of the transforming growth factor（TGF-β） superfamily，mainly expressed in the granulosa cells of ovarian in women，which can be used as a marker to evaluate the ovarian reserve. There are three types of AMH receptor，Ⅰ，Ⅱ and Ⅲ type. In human， AMH acts via receptor Ⅱ. PCOS and POF are the main reason of infertility. It was found that sera AMH was at high level in PCOS， at low level in POF， but at almost normal level in precocious puberty. AMH， as well as its receptor Ⅱ， gene polymorphisms are related with PCOS and POF. AMH may be an important marker for the diagnosis of PCOS， POF， PA， and it also be a guided marker for PCOS treatment.

Key words: Anti-mullerian hormone, Polycystic ovary syndrome, Ovarian failure, premature, Puberty, precocious