Journal of International Reproductive Health/Family Planning

Journal of International Reproductive Health/Family Planning ›› 2010, Vol. 29 ›› Issue (2): 99-101.

• 综述 • Previous Articles     Next Articles

The Advance in the Study on SHBG and Insulin Resistant

JIANG Wen-ying;CHEN Dan-qing   

  1. Departmentof Gynaecology and Obstetrics，the First People’s Hospital，Hangzhou 310016，China （JIANG Wen-ing）；Wamen’s Hospital，School of Medicine, Zhejiang University, Hangzhou 310006, China（CHEN Dan-ing）
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-03-15 Online:2010-03-15

PDF (PC)

7172

Abstract: Sex hormone binding globulin（SHBG）is a glycoprotein secreted by the liver that binds sex
steroids in the circulation. In humans，SHBG binds and transports the biologically most important androgens
and estrogens in the blood，and regulates the access of these steroids to their targets tissues. The SHBG is
down-egulated by insulin and low SHBG level is associated with insulin resistant. SHBG concentration is
changed by age and menstrual cycles，and the relationship of SHBG and insulin resistant is different in
people. SHBG has a association with a variety of insulin resistant conditions including diabetes mellitus，
polycystic ovary syndrome and metabolis syndrome.

Key words: Sex hormone binding globulin, nsulin resistant, Diabetes mellitus, Polycystic ovarysyndrome, Metabolis syndrome