Abstract: Gestational diabetes mellitus（GDM）is defined as glucose intolerance of various degrees that is first detected during pregnancy and developed from progressive insulin resistance that begins near mid-pregnancy which maybe associated with increased secretion of adipocytokine. Most studies recently reveal that
obesity is a risk factor of developing GDM and perinatal outcomes will be influenced by materal body mass index and weight gain during pregnancy. Women with GDM are at high risk for progressing to diabetes after pregnancy and their offspring also are more likely to developing obesity and abnormal glucose metabolism.

Key words: Gestational diabetes mellitus, Insulin resistance, Obesity, Perinatal outcomes