Abstract: Objective: To explore the application of the HPV screening combined with ThinPrep cytology （ＴＣＴ） and loop electrosurgical excision proceduｒｅ （ＬＥＥＰ） ｉｎ diagnosis treatment of the cervical lesions of high-risk viral infections. Methods：From January 2013 to January 2014, 1 126 women were tested by HPV testing combined with ThinPrep cytology （ＴＣＴ） in our hospital. Those patients with positive resulｔ（ｓ） （ｏne or two tests) underwent the colposcopic biopsy and pathological exam. Those patients with high-risk HPV were divided into 3 groups, A9, A7 and A5/A6, while those patients with high-risk HPV and cervical lesions of high-risk pattern were treated by LEEP knife resection under electronic colposcope. The incidence of high-risk HPV cervical infection, the results of follow-up and treatment and the incidence of different types of cervical lesions in those patients with different high-risk HPV ws classification were compared. Results：Fourteen types of high-risk type HPV were detected in 1 126 women. The incidence of high-risk HPV was 8.5% （96/1 126）. There was not significant difference in the incidences of different types of cervical lesions in those patients with different high-risk HPV ws classification the three groups （Ｐ＞０．０５）. After three to six months of treatment, the overall rate of the inverted HPV negative infection was 74.0% （71/96）． There was not significant difference in this rate in 3 groups differencｅ （ｔhe A9 group, 78.9% （30/38）; the A7 group, 67.7% （21/31）; the A5/A6 group, 74.1% （２0/27;χ2=3.272, P＞0.0５）. Conclusions：LEEP is a effective method to treat those patients with different high-risk HPV ws classification infection.

Key words: Human papillomavirus, Cervical intraepithelial neoplasia, Carcinoma in situ, Uterine cervical neoplasms