Abstract: Objective: To investigate the efficacy and safety of the termination of second trimester pregnancy with mifepristone and misoprostol in patients with previous cesarean section. Methods：105 women with scarred uterins （ｇｒｏｕｐ １） ｄue to previous cesarean and 105 matched patients （ｇroup ２） without uterine scar were retrospectively analyzed. They underwent termination of second trimester pregnancy with mifepristone and misoprostol. The success rate of abortion，the induction-to-delivery interval，the occurrence rate of retained placenta，uterine rupture and hemorrhage were compared. Results：There were no significant differences in the abortion rate （９６．２％ ｖｓ． ９４．３％），the induction-to-delivery intervａｌ （both 5 ｈ） and the retained placenta rate （１５.2% vs. 7.6％） ｂｅtween the two groupｓ （Ｐ＞０．０５）． There was only one case of uterine rupture in the group 1. Conclusions：Mifepristone combined with misoprostol are safe and effective in the termination of second trimester pregnancy for those patients with scarred uterins. But during the termination of pregnancy，overall evaluation and careful monitoring are necessary.

Key words: Mifepristone, Misoprostol, Pregnancy trimester, second, Uterus, Cicatrix, Abortion, induced