间充质-上皮转化在女性生殖系统中的研究进展

doi:10.12280/gjszjk.20200339

摘要/Abstract

摘要：

间充质-上皮转化（mesenchymal-epithelial transition,MET）是间充质细胞、上皮细胞相互转化的一种生物学特性,是人体多种生物学过程的基础,在女性生殖系统形成和发育过程中扮演了关键角色。间充质细胞向上皮细胞的转化在胚胎发育早期阶段就已开始,并且参与了多个器官和组织的形成。此外,MET不仅帮助了子宫内膜上皮细胞生理性再生以及蜕膜化来调节胚胎的黏附和植入,在子宫内膜异位症、生殖系统肿瘤等疾病的发生、浸润中也发挥了重要作用。对MET相关研究进展进行综述,以期为女性生殖系统结构与功能的研究及相关疾病的防治提供思路和方向。

关键词: 间质-上皮转化, 上皮-间质转化, 不育, 女（雌）性, 子宫内膜, 胚胎发育, 子宫内膜异位症, 肿瘤

Abstract:

Mesenchymal epithelial transition (MET) is a biological characteristic of the transformation between mesenchymal cells and epithelial cells. It is the basis of many biological processes in the human body. It also plays a key role in the formation and development of the female reproductive system. MET begins at the early stage of embryo development, which is involved in the formation of multiple organs and tissues. In addition, MET not only helps the physiological regeneration of endometrial epithelial cells and the decidualization to regulate the adhesion and implantation of embryos, but also plays an important role in the pathological process of reproductive diseases such as endometriosis and tumors. This article reviews the research progress related to MET in order to provide ideas and directions for the research on the structure and function of female reproductive system and the prevention and treatment of reproduction-related diseases.

Key words: Mesenchymal-epithelial transition, Epithelial-mesenchymal transition, Infertility, female, Endometrium, Embryonic development, Endometriosis, Neoplasms

王斌, 高明霞, 沈豪飞, 王一青, 张学红. 间充质-上皮转化在女性生殖系统中的研究进展[J]. 国际生殖健康/计划生育, 2021, 40(1): 44-48.

WANG Bin, GAO Ming-xia, SHEN Hao-fei, WANG Yi-qing, ZHANG Xue-hong. Research Progress of Mesenchymal-Epithelial Transition in Female Reproductive System[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(1): 44-48.

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