Kisspeptin与妊娠及其相关疾病关系的研究进展

doi:10.12280/gjszjk.20210122

摘要/Abstract

摘要：

Kisspeptin是由kiss-1基因编码的一种神经肽,早期被认为具有抑制肿瘤转移、调控生殖内分泌等作用。Kisspeptin及其受体广泛分布于脑、垂体、卵巢、子宫和胎盘等多种组织,在子宫内膜中的表达呈周期性变化,分泌晚期的子宫内膜间质细胞中kisspeptin的表达显著升高,在妊娠早期胎盘和母体血浆中kisspeptin的浓度也急剧增加。近年研究表明,kisspeptin在蜕膜化、胎盘形成和胚胎植入等妊娠生理过程中起重要的调控作用,并可参与妊娠期葡萄糖稳态的维持,kisspeptin水平的变化与复发性流产、子痫前期、妊娠期糖尿病等妊娠相关疾病有关。综述kisspeptin在生理妊娠过程中的作用机制及其与妊娠相关疾病关系的研究进展。

关键词: 亲吻素, 妊娠结局, 流产,习惯性, 先兆子痫, 糖尿病,妊娠

Abstract:

Kisspeptin, a neuropeptide encoded by kiss-1 gene, has been considered to inhibit tumor metastasis and regulate reproductive endocrine. Kisspeptin and its receptors are widely distributed in the brain, pituitary gland, ovary, uterus, placenta and other tissues. The expression of kisspeptin in the endometrium changes periodically, which is significantly increased in the endometrial stromal cells of the late secretion period. The concentration of kisspeptin in placenta and maternal plasma also increases sharply in the first trimester. Recent studies have shown that kisspeptin plays an important role in regulating the physiological processes of pregnancy such as decidualization, placenta formation and embryo implantation. Kisspeptin is also involved in the maintenance of glucose homeostasis during pregnancy. The abnormal level of kisspeptin is associated with pregnancy-related diseases such as recurrent abortion, preeclampsia and gestational diabetes mellitus. In this paper, the role of kisspeptin and the mechanism in the physiological pregnancy and the pregnancy-related diseases are reviewed.

Key words: Kisspeptins, Pregnancy outcome, Abortion, habitual, Pre-eclampsia, Diabetes, gestational

韩昕宇, 吴天强, 冯晓玲. Kisspeptin与妊娠及其相关疾病关系的研究进展[J]. 国际生殖健康/计划生育, 2021, 40(5): 420-426.

HAN Xin-yu, WU Tian-qiang, FENG Xiao-ling. Kisspeptin, Pregnancy and Related Diseases[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(5): 420-426.

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