卵巢抵抗综合征不孕患者拮抗剂方案助孕鲜胚移植成功分娩一例

doi:10.12280/gjszjk.20210634

国际生殖健康/计划生育 ›› 2022, Vol. 41 ›› Issue (4): 294-297.doi: 10.12280/gjszjk.20210634

卵巢抵抗综合征不孕患者拮抗剂方案助孕鲜胚移植成功分娩一例

陈亚楠, 郭加丽, 李泽武, 杨爱军()

272000 济宁医学院临床医学院（陈亚楠）；济宁医学院附属医院生殖医学科（郭加丽,李泽武,杨爱军）

收稿日期:2021-12-28 出版日期:2022-07-15 发布日期:2022-07-20
通讯作者: 杨爱军 E-mail:yajlws0618@yeah.net
基金资助:
国家自然科学基金(81701526);济宁医学院国家自然（社会）科学基金(JYP201844)

A Case of Successful Delivery in An Infertile Patient with Ovarian Resistance Syndrome: Treated with Antagonist Protocol and Fresh-Embryo Transfer

CHEN Ya-nan, GUO Jia-li, LI Ze-wu, YANG Ai-jun()

School of Clinical Medicine of Jining Medical University, Jining 272000, Shandong Province, China (CHEN Ya-nan); Department of Reproductive Medicine, Affiliated Hospital of Jining Medical University, Jining 272000, Shandong Province, China (GUO Jia-li, LI Ze-wu, YANG Ai-jun)

Received:2021-12-28 Published:2022-07-15 Online:2022-07-20
Contact: YANG Ai-jun E-mail:yajlws0618@yeah.net

摘要/Abstract

摘要：

卵巢抵抗综合征（resistant ovarian syndrome,ROS）是一种病因不明的生殖内分泌疾病,发病率低,主要导致不孕,并且治疗过程复杂,易引起患者焦虑情绪。报告1例ROS不孕患者通过体外受精-胚胎移植（in vitro fertilization and embryo transfer,IVF-ET）助孕成功的病例。患者因原发性不孕,促排卵治疗无效,对外源性促性腺激素（gonadotropin,Gn）反应低下,在外院经历多个IVF-ET周期未孕。经调整Gn水平,最终采用拮抗剂方案鲜胚移植,获得活产。通过对相关文献进行回顾性分析,探讨该病例治疗成功的可能原因,以期为ROS患者的临床诊疗方案提供新思路,降低治疗费用的同时获得满意的助孕结局。

关键词: 卵巢, 综合征, 不育,女（雌）性, 促性腺素类, 体外受精, 胚胎移植

Abstract:

Resistant ovarian syndrome (ROS) is a reproductive endocrine disorder of unknown etiology, with a low incidence and mainly leading to infertility. The complicated treatment and long procedure cause the anxiety of ROS patients. In this paper, we report a case of an infertile patient with ROS, who underwent in vitro fertilization and embryo transfer (IVF-ET) for successful pregnancy. The patient had failed to conceive after several in vitro fertilization treatments at an outside hospital because of her primary infertility, ineffective ovulation treatment, and low response to exogenous gonadotropin (Gn). In the following treatment in our hospital, we adjusted her Gn level and finally obtained a live birth after fresh embryo transfer with an antagonist regimen. Through a retrospective analysis of the relevant literatures, we hope to explore the possible reasons for the successful treatment of this ROS case, and to provide new ideas for the clinical management of ROS patients, so that we can achieve a more satisfactory pregnancy outcome while reducing the cost of treatment.

Key words: Ovary, Syndrome, Infertility, female, Gonadotropins, Fertilization in vitro, Embryo transfer

陈亚楠, 郭加丽, 李泽武, 杨爱军. 卵巢抵抗综合征不孕患者拮抗剂方案助孕鲜胚移植成功分娩一例[J]. 国际生殖健康/计划生育, 2022, 41(4): 294-297.

CHEN Ya-nan, GUO Jia-li, LI Ze-wu, YANG Ai-jun. A Case of Successful Delivery in An Infertile Patient with Ovarian Resistance Syndrome: Treated with Antagonist Protocol and Fresh-Embryo Transfer[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(4): 294-297.

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卵巢抵抗综合征不孕患者拮抗剂方案助孕鲜胚移植成功分娩一例

A Case of Successful Delivery in An Infertile Patient with Ovarian Resistance Syndrome: Treated with Antagonist Protocol and Fresh-Embryo Transfer

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