单个核细胞在生殖系统疾病治疗中的应用

doi:10.12280/gjszjk.20220034

摘要/Abstract

摘要：

单个核细胞（mononuclear cells,MNCs）是多种免疫细胞及多能干细胞/祖细胞组成的细胞群体,根据来源主要分为脐带血单个核细胞、骨髓单个核细胞和外周血单个核细胞。MNCs在体内可发挥抑制细胞凋亡、促进损伤组织干细胞的分化和增殖、促进新生血管形成和调节局部免疫微环境的作用,作用机制可能与归巢及分泌与旁分泌作用有关。MNCs在生殖系统疾病治疗中的应用研究主要涉及卵巢早衰、宫腔粘连和反复种植失败,研究所涉及的MNCs种类、移植途径及临床试验开展情况各有不同。外泌体、生物支架及基因治疗有望成为MNCs治疗女性生殖系统疾病的新探索点。但MNCs在应用中仍存在不容忽视的问题,包括移植途径及浓度对效果的影响等。

关键词: 细胞移植, 细胞和组织疗法, 女（雌）性泌尿生殖系统疾病, 治疗结果, 单个核细胞

Abstract:

Mononuclear cells (MNCs) are a cell population of a variety of immune cells and pluripotent stem/progenitor cells. According to the source, they are mainly divided into umbilical cord blood mononuclear cells, bone marrow mononuclear cells and peripheral blood mononuclear cells. MNCs can inhibit apoptosis, and promote the differentiation and proliferation of stem cells in the damaged tissues. MNCs can also promote angiogenesis, and regulate the local immune microenvironment in vivo. The mechanisms of action may be related to homing, secretion and paracrine effects. The application researches of MNCs in the treatment of reproductive system diseases mainly involve premature ovarian failure, intrauterine adhesions and repeated implantation failure. The types of MNCs, tranplantation approaches and the development of clinical trials involved in studies are different. Exosomes, biological scaffolds and gene therapy are expected to become new exploration points for MNCs to treat female reproductive system diseases. However, there are still problems that cannot be ignored in the application of MNCs, including the effect of transplantation route and concentration on the treatment.

Key words: Cell transplantation, Cell- and tissue-based therapy, Female urogenital diseases, Treatment outcome, Mononuclear cells

高景悦, 于璇, 臧朝雯, 邓晓惠. 单个核细胞在生殖系统疾病治疗中的应用[J]. 国际生殖健康/计划生育, 2022, 41(3): 240-244.

GAO Jing-yue, YU Xuan, ZANG Zhao-wen, DENG Xiao-hui. Application of Mononuclear Cells in the Treatment of Reproductive System Diseases[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(3): 240-244.

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