生殖道微生物组学与慢性子宫内膜炎的相关性

doi:10.12280/gjszjk.20220415

摘要/Abstract

摘要：

慢性子宫内膜炎（chronic endometritis，CE）是一种子宫内膜局部炎症性疾病，多数患者无症状或伴有轻微症状，易被漏诊。研究发现，CE与不孕症、反复种植失败以及复发性流产等不良生殖结局关系紧密。CE主要由子宫内膜的病原体感染引起，明确CE的易感微生物群及其致病性有助于提高CE诊断的准确性和治疗的针对性。微生物组学能更加全面地评估CE患者的子宫内膜微生物组成，为未来CE的个体化治疗提供更多可能。综述近年女性生殖道微生物组学在CE中的研究进展，以期为CE的诊治提供新思路。

关键词: 子宫内膜炎, 慢性病, 微生物群, 妊娠结局, 治疗

Abstract:

The chronic endometritis (CE), a subtle lesion and persistent inflammation without clinical symptom or only accompanied by mild disturbances, is easily overlooked. Studies have revealed a strong link between CE and unfavorable reproductive outcomes such as infertility, recurring implant failure and recurrent abortion. Since endometrial infections are the main cause of CE, pinpointing these pathogenic microorganisms and their propensity for endometrial infection will aid in improving CE diagnosis and therapy. Microbiome can more comprehensively evaluate the endometrial microbial composition of patients with CE, which will provide more possibilities for the individualized treatment of CE in the future. Hence, this paper summarize the research progress of female reproductive tract microbiome in patients with CE, in order to provide new ideas for the diagnosis and treatment of CE.

Key words: Endometritis, Chronic disease, Microbiota, Pregnancy outcome, Therapy

张路, 高彩虹, 包洪初. 生殖道微生物组学与慢性子宫内膜炎的相关性[J]. 国际生殖健康/计划生育杂志, 2023, 42(2): 167-171.

ZHANG Lu, GAO Cai-hong, BAO Hong-chu. The Correlation between Reproductive Tract Microbiome and Chronic Endometritis[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(2): 167-171.

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