辅助生殖技术与子代安全

doi:10.12280/gjszjk.20220556

摘要/Abstract

摘要：

辅助生殖技术在生命早期对于胚胎的人工干预，是否会为出生的子代远期健康和安全带来隐患，一直是人类大健康问题的重点议题。回顾人工授精、体外受精-胚胎移植及其衍生技术等辅助生殖技术的技术要点，从不良妊娠结局、出生缺陷、远期健康问题、基因印迹异常等几个方面，对子代安全性问题的研究进行了总结分析。大多数的研究支持人工辅助生殖技术的安全性，认为辅助生殖技术出生的子代不良事件发生率并未增加。但鉴于大多数研究数据集中在婴幼儿时期，因此，仍需对辅助生殖技术出生的子代进行长期的健康追踪随访，以获得子代青少年及成年后健康数据，进一步论证辅助生殖技术子代安全性问题。

关键词: 生殖技术, 辅助, 体外受精, 胚胎移植, 线粒体置换技术, 安全性, 先天畸形

Abstract:

Whether the artificial intervention of assisted reproductive technology（ART） in the early life will bring potential risks to the long-term health and safety of the offspring has always been a key issue of human health. This article reviews the key points of ART, such as artificial insemination, in vitro fertilization-embryo transfer and its derivative technology, and summarizes and analyzes the safety of offspring from the aspects of adverse pregnancy outcomes, birth defects, long-term health problems, and genetic imprinting abnormalities. Most studies support the safety of ART and believe that children born by ART do not increase the incidence of adverse events. However, since most research data focus on infants and young children, it is still necessary to conduct the long-term health follow-up of children born by ART to obtain health data in adolescents and adulthood, and to further demonstrate the safety of children born by ART.

Key words: Reproductive techniques, assisted, Fertilization in vitro, Embryo transfer, Mitochondrial replacement technique, Safety, Congenital abnormalities

王春艳, 王婕妤, 程静娴, 王吟霜, 罗桂英. 辅助生殖技术与子代安全[J]. 国际生殖健康/计划生育杂志, 2023, 42(3): 226-230.

WANG Chun-yan, WANG Jie-yu, CHENG Jing-xian, WANG Yin-shuang, LUO Gui-ying. Assisted Reproductive Technology and Offspring Safety[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(3): 226-230.

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