国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2009, Vol. 28 ›› Issue (6): 355-357.

• 综述 • 上一篇    下一篇

线粒体功能与精子活力

周秀芬;姜宏   

  1. 237005安徽省六安市， 六安市人民医院妇产科（周秀芬）;解放军105医院生殖医学中心（姜 宏）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-11-15 发布日期:2009-11-15

Mitochondrial Function and Sperm Motility

ZHOU Xiu-fen;JIANG Hong   

  1. Department of Gynaecology and Obstetrics， the People’s Hospital of Luan City， Luan 237005， China（ZHOU Xiu-fen）; Repoductive Medicine Center， PLA 105 Hospital， Hefei 230031， China (JIANG Hong)
  • Received:1900-01-01 Revised:1900-01-01 Published:2009-11-15 Online:2009-11-15

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摘要： 精子活力是衡量精液质量和男性生育力的一个重要指标，在男性不育患者中约19%为精子活力低下所致。精子运动所需能量来自线粒体呼吸链的氧化磷酸化，各种原因导致的线粒体结构和功能改变，如膜电位的降低，酶活性或表达量异常以及线粒体DNA（mtDNA）的突变或缺失等均可导致线粒体能量合成障碍，精子活力降低。对近年有关线粒体功能与精子活力相关性研究进展综述，旨在探讨精子活力低下的发病机制以及临床治疗弱精子症的可能途径。

关键词: 精子, 活力, 线粒体, 线粒体DNA(mtDNA)

Abstract: Sperm motility is an important indicator of the measurement of semen quality and male fertility， and approximately 19% of patients with male infertility are caused by the lower of sperm motility. The energy required for sperm motility comes from the oxidative phosphorylation of mitochondrial respiratory chain. The changes of mitochondrial structure and function caused by various reasons， such as the reduction of membrane potential， abnormality of enzyme activity or expression， and the mutation or deletion of mitochondrial DNA （mtDNA）， may result in the dyssynthesis of mitochondrial energy and depression of sperm motility. This article reviews the recent advancements of the correlation between mitochondrial function and sperm motility in order to explore the pathogenesy of poor motility of sperm and possible pathway of clinical treatment for asthenospermia.

Key words: Sperm, Motility, Mitochondria, Mitochondrial DNA （mtDNA）