国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (1): 41-44.

• 综述 • 上一篇    下一篇

雌激素及其受体与原因不明复发性流产

马丽综述;杨雪峰审校   

  1. 郑州大学第三附属医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-01-15 发布日期:2010-01-15

Estrogen and Its Receptor with Unexplained Recurrent Spontaneous Abortion

MA Li;YANG Xue-feng   

  1. Department of Obstetrics and Gynecology, The Third Affiliated hospital School of Zhengzhou University
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-01-15 Online:2010-01-15

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摘要： 复发性自然流产病因复杂，仍有近50%的复发性流产病因不明。辅助性T细胞1型(Th1)和2型(Th2)失衡是复发性流产的重要特征。雌激素与其受体结合后可通过基因途径和快速信号反应途径影响T细胞功能，进而影响Thl／Th2型细胞因子间的动态平衡，可能导致复发性流产。雌激素受体在绒毛和蜕膜组织中表达量降低也可能导致复发性流产的发生。通过对雌激素受体与T细胞功能的分析，着重对雌激素受体与复发性流产的相关研究综述。

关键词: 复发性流产, 雌激素, 雌激素受体, T淋巴细胞

Abstract: The Cause of recurrent spontaneous abortion (RSA) is complicated, and almost 50% of RSA unexplained. The imbalance between T helper cell type 1 (Th1) and type 2 (Th2) is the key character of the RSA. Estrogen and its receptor may affect the function of T cell through the way of gene and the fast signal reaction path, then affect the dynamic balance of Thl/Th2 cell factor，eventually cause the RSA. The low expression of estrogen acceptor in the villi and decidual tissues may cause the RSA. We analyse the function of estrogen receptor and T cell, especially focused on the estrogen receptor to find the cause of RSA.

Key words: Recurrent spontaneous abortion, Estrogen, Estrogen receptor, Tlymphocytes