国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (2): 78-80.

• 综述 • 上一篇    下一篇

Wnt信号途径及其调节因子Dkk 与子宫内膜容受性

刘春喜;苏迎春;孙莹璞   

  1. 450052郑州大学第一附属医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-03-15 发布日期:2010-03-15

Investigation of Wnt Signaling and Regulatory Factor Dkk in Endometrial Receptivity

LIU Chun-xi, SU Ying-chun, SUN Ying-pu   

  1. The Reproductive Medical Center of the First Affiliated Hospital of ZhengzhouUniversity, Zhengzhou 450052, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-03-15 Online:2010-03-15

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摘要： Wnt信号通路是存在于生物体内的一条极其保守的信号转导通路，其相关基因在胚胎种植前后的子宫表达，且受标准的种植相关基因调控，如LIF 和HOXA鄄10。Dkk（Dickkopf）是一种分泌蛋白，通过调节Wnt信号转导途径发挥作用，其在子宫内膜表面表达有时空特异性，种植期表达增高，引起子宫内膜分泌期容受性发生改变。Wnt信号和Dkk 参与调节子宫内膜容受性，是其关键因素之一。

关键词: Dkk 蛋白, Wnt, 子宫内膜容受性, 胚胎着床

Abstract: Wnt singaling path ways play important role in various processes such as fetal development tumorigenesis and homeostasis. Wnt signaling related genes exhibit spatiotemporal expression in the uterus during mouse peri-implantation and that they are tightly regulated by critical implantation-related genes, such
as LIF and HOXA-10. Wnt/beta-catenin signaling, which has been proven to participate in tumorigenesis and early embryo development. Dkk（Dickkopf）family plays an critical role in embryo implantation by mediating Wnt signaling and induce the change in endometrial receptivity in space-time specificitily. Wnt signaling and Dkk are very critical factor in endometrium during the peri-implantation period.

Key words: Dkk protein, Wnt, Endometrial receptivity, Embryo implantation