子宫内膜容受性评估研究进展

doi:10.12280/gjszjk.20200535

摘要/Abstract

摘要：

胚胎着床是复杂且精密化的过程,主要由胚胎、子宫内膜及两者的交互对话共同调控。随着胚胎实验室技术的发展,胚胎质量的提高及胚胎选择体系的完善已经取得了突破性的进展,但子宫内膜容受性的评价体系及标准还未阐明。近年来,随着个体化胚胎移植（personalized embryo transfer,pET）概念的提出,子宫内膜容受性的精准评估成为焦点。国内外对于如何评估子宫内膜容受性的研究从未间断,从最初的超声及胞饮突检查到现在的各种分子标志物不断被提出,再到子宫内膜容受性阵列、子宫内膜容受性图谱及蛋白质组学、脂质组学等新技术的应用研究。综述评估子宫内膜容受性的各种指标及其临床实践应用与研究,以期为临床工作提供帮助,指导pET,提高临床妊娠率和活产率。

关键词: 胚胎植入, 蛋白质组学, 子宫内膜容受性, 子宫内膜容受性阵列, 个体化胚胎移植

Abstract:

Embryo implantation is a complicated and sophisticated process, which is mainly regulated by embryo, endometrium and the interaction between the two. With the development of embryo laboratory technology, the embryo quality and embryo selection system have been improved significantly. However, the evaluation system and standard of endometrial receptivity have not been clarified yet. In recent years, the accurate assessment of endometrial receptivity has become a focus with the proposal of personalized embryo transfer (pET). More and more researches were focused on how to assess endometrial receptivity, from the initial ultrasound and pinopodes examination to various molecular markers, and to endometrial receptivity array, endometrial receptivity profile and proteomics, lipidomics and other indicators. The author hereby reviews various indicators for evaluating endometrial receptivity. It is helpful for the future work and study, such as individualized embryo transfer, so as to improve clinical pregnancy rate and live birth rate.

Key words: Embryo implantation, Proteomics, Endometrial receptivity, Endometrial receptivity array, Personalized embryo transfer

谢娱新, 王靖莹, 杨超, 姜婷, 陈晓旭, 路英丽. 子宫内膜容受性评估研究进展[J]. 国际生殖健康/计划生育, 2021, 40(3): 231-236.

XIE Yu-xin, WANG Jing-ying, YANG Chao, JIANG Ting, CHEN Xiao-xu, LU Ying-li. Progress in Evaluation of Endometrial Receptivity[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(3): 231-236.

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