国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (1): 10-13.

• 综述 • 上一篇    下一篇

男性迟发性性腺功能减退症的发病机制与流行病学

李宏军 ，谷翊群   

  1. 100730 北京，中国医学科学院北京协和医学院 北京协和医院泌尿外科（李宏军）；国家人口计生委科学技术研究所 （谷翊群）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-01-15 发布日期:2011-01-15

The Mechanism and Epidemiological Research on Late鄄onset Hypogonadism in Males

LI Hong－jun, GU Yi-qun   

  1. Department of Urology，Peking Union Medical College Hospital，Chinese Academy of Medical Science，Beijing 100730，China（LI Hong鄄jun）；Department of Male Clinic Research，National Research Institute for Family Planning，Beijing 100081，China（GU Yi鄄qun）
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-01-15 Online:2011-01-15

PDF (PC)

7645

摘要： 中老年男性迟发性性腺功能减退症（late鄄onset hypogonadism，LOH）的发病机制是多种机
制损害雄激素的正常分泌和生物活性，包括雄激素水平下降和雄激素受体异常，是原发性和继发性因素
共同作用的结果。综述LOH 的发病机制、发病率及危险因素，后者包括疾病和药物的影响、过度肥胖、不
良生活方式、环境与遗传因素的影响、精神心理因素、社会经济因素和文化教育水平。

关键词: 男人, 年龄因素, 性腺功能减退症, 睾酮, 流行病学, 病因学

Abstract: With the rapid aging progression for the human being，more concern was focused on the
research of late鄄onset hypogonadism（LOH）. In the review article，the mechanism and epidemiological research
on LOH is sumarized. The mechanism of LOH is the combinated effects of primary and secondary factors，
which achieved by many pathways to damage the secretion and bio鄄activity of androgen including the androgen
level and androgen receptor（AR）. Morbidity，susceptibility and risk factors are reviewed including diseases
and medication，obesity，untoward life style，environmental and genetic factors，psychological factor，social鄄
economic factors and cultural level.

Key words: Men, Age factors, Hypogonadism, Testosterone, Epidemiology, Etiology