国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (2): 111-114.

• 综述 • 上一篇    下一篇

人绒毛膜促性腺激素在辅助生殖技术中的研究进展

马从顺, 邢福祺   

  1. 510515 广州，南方医科大学南方医院妇产科生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-03-15 发布日期:2011-03-15

Clinical Application of Human Chorionic Gonadotropin Adminstration in Assisted Reproductive Technology

MA Cong-shun， XING Fu-qi   

  1. Reproductive Technology Center， Nanfang Hospital， Southern Medical University， Guangzhou 510515， China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-03-15 Online:2011-03-15

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摘要： 人绒毛膜促性腺激素（hCG）由胎盘滋养细胞产生。随着尿源性纯hCG以及重组hCG的出现，其已广泛用于临床人工辅助生殖技术（ART）中。近年研究发现，hCG用于体外受精/胞浆内单精子注射（IVF/ICSI）周期前预处理可以提高胚胎质量及临床妊娠结局；hCG可在黄体中期长方案及拮抗剂方案中替代黄体生成激素（LH）或卵泡刺激素（FSH）用于晚卵泡期超促排卵；同时hCG还可能通过介导免疫机制促进胚胎着床等。hCG在ART临床中起着不可替代的作用。

关键词: 绒毛膜促性腺激素, 生殖技术, 辅助, 卵泡期, 自身免疫

Abstract: Human chorionic gonadotropin（hCG） is produced by placental syneytiotrophoblast. Human urinary u-hCG and recombinant hCG， were now widely administered in assistant reproductive technique（ＡＲＴ）. Recently， the embryo quality and clinical outcomes were improved by using hCG for pretreatment before IVF/ICSI cycles. hCG can be used for completing cotrolled ovarian stimulation in late follicular phase as a substitution of LH or FSH in both long?-protocol and antagonist-protocol， and for enhancing embryo invasion by immunologic mechanism. Generally， hCG plays an irreplaceable role in the clinic of ART.

Key words: Chorionic gonadotropin, Reproductive techniques, assisted, Follicular phase, Autoimmunity