国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (3): 226-229.

• 综述 • 上一篇    下一篇

人卵巢组织玻璃化冷冻与移植的研究进展

郑 轶, 周 平   

  1. 230031 合肥，安徽医科大学第一附属医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-05-15 发布日期:2011-05-15
  • 通讯作者: 周 平

Progress in Research on Vitrification and Transplantation of Human Ovarian Tissues

ZHENG Yi，ZHOU Ping   

  1. Reproductive Medicine Center，the First Affiliated Hospital of Anhui Medical University， Hefei 230031，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-05-15 Online:2011-05-15
  • Contact: ZHOU Ping

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摘要： 人卵巢组织冷冻对于保存生育力有重要作用。现常用冷冻方法包括玻璃化冷冻和程序化冷冻。大量研究表明，前者冷冻效果优于后者。迄今为止，玻璃化冷冻仍缺少标准化的程序。作为恢复癌症患者生殖内分泌功能的重要手段，卵巢组织移植近年得到发展，但仍存在许多问题有待进一步研究。综述玻璃化冷冻效果的影响因素、减少缺血再灌注损伤方法、移植后卵巢功能恢复所需时间及生存期限的影响因素。

关键词: 卵巢, 低温保存, 组织保存, 移植, 自体, 生育力

Abstract: Human ovarian tissues cryopreservation plays an important role in preserving female’s fertility. Currently， technologies of ovarian tissue cryopreservation mainly include slow freezing protocol and vitrification protocol. A large number of studies shown that vitrification frozen was better. However， vitrification there was not the standardized protocol of until now. Ovarian tissue transplantation is an important method in the restoration of female’s fertility， which has been developed in recent year salthough needs for more study. In this paper， we reviewed the factors influencing vitrification， the method reducing ischemia?-reperfusion injury， and the factors of functional recovery and survival period after transplantation.

Key words: Ovary, Cryopreservation, Tissue preservation, Transplantation, autologous, Fertility