国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (2): 119-122.

• 综述 • 上一篇    下一篇

HOXA10及其下游基因Emx2、整合素β3与子宫内膜容受性


高琦,蔡霞   

  1. 830054乌鲁木齐，新疆医科大学第一附属医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-03-15 发布日期:2012-03-15
  • 通讯作者: 蔡霞

HOXA10 with Its Downstream Genes Emx2, Integrinβ3 and Endometrial Receptivity

GAO Qi，CAI Xia   

  1. The Reproductive Center of the First Affiliated Hospital of Xinjiang Medical University，Urumqi 830054，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-03-15 Online:2012-03-15
  • Contact: CAI Xia

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摘要： 同源框基因HOXA10是多基因家族的转录调节基因之一，在决定子宫内膜容受性方面起主导作用，主要参与胚胎着床控制及内膜蜕膜化。研究发现，该机制可能与内皮素A型受体、锌指转录因子 9、酌-氨基丁酸pi受体、3-磷酸甘油酸酯脱氢酶、钙蛋白酶5、香烟烟雾提取物、p300/CBP相关因子、色氨酸2和3-双加氧酶调控有关。整合素茁3及Emx2是HOXA10调控的下游基因，在月经周期分泌期，HOXA10上调，抑制子宫内膜细胞Emx2表达，而激活整合素茁3表达，在胚胎着床及基质细胞蜕膜化过程中发挥重要作用。HOXA10调控紊乱可导致不孕。

关键词: 同源盒结构域蛋白质类, 基因表达调控, 基因, 同源盒, 整合素β3, 不育, 女(雌)性, 子宫内膜

Abstract: Homeobox Gene HOXA10, one member of the multi -gene family of transcriptional regulation, plays an important role in determining endometrial receptivity. HOXA10 is mainly involved in regulation of embryo implantation and endometrial decidualization. The mechanism may be related to endothelin type A receptor, Kruppel-like factor 9, GABA（A）pi recepto, 3-phosphoglycerate dehydrogenasecalpain, cigarett smoke, p300/CBP-associated factor, tryptoph an 2, 3-dioxygenase. Integrin茁3 and Emx2 are downstream genes of HOXA10 in endometrial cells. HOXA10 inhibites expression of Emx2, but activates integrin茁3,which play an important role in embryo implantation and decidualization of stromal cells. The abnormal regulation of HOXA10 expression causes infertility.

Key words: Homeodomain proteins, Gene expression regulation, Genes, homeobox, Integrin beta3, Infertility, female, Endometrium