国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (2): 129-132.

• 综述 • 上一篇    下一篇

卵巢癌转移相关microRNAs研究进展

周星辰,邱丽华   

  1. 200001上海交通大学医学院附属上海仁济医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-03-15 发布日期:2012-03-15

The Metastasis-associated MicroRNAs in Ovarian Cancer

ZHOU Xing-chen，QIU Li-hua   

  1. Department of Obstetrics and Gynecology，Shanghai Renji Hospital，School of Medicine，Shanghai Jiao Tong University， Shanghai 200001, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-03-15 Online:2012-03-15

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摘要： 微小RNA是一种内源性非编码小RNA，能在转录后水平负调节靶基因的表达。而肿瘤相
关的微小RNA有类似于癌基因或抑癌基因的作用。近年研究发现，一些微小RNA可以通过不同的途径作
用于靶基因，对卵巢癌的侵袭转移有促进或抑制作用。明确这些微小RNA及其在卵巢癌侵袭转移方面的
作用机制将为卵巢癌的治疗提供新靶点。

关键词: 卵巢肿瘤, 肿瘤侵润, 肿瘤转移, 微小RNAs

Abstract: MicroRNAs（miRNAs）, a class of small non-coding RNAs, negatively regulate the
expression of target genes at the post -transcriptional level. The tumor -associated miRNAs have been
demonstrated to act as either oncogenes or tumor suppressors. Recent studies suggested that some miRNAs
acting on target genes through various pathways, might play roles in regulating tumor metastasis in ovarian
cancer. Therefore，it is possible to find new targets for therapy of ovarian cancer by studying the effects of
miRNAs on ovarian cancer metastasis.

Key words: Ovarian neoplasms, Neoplasm invasiveness, Neoplasm metastasis, MicroRNAs