国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (2): 133-136.

• 综述 • 上一篇    下一篇

孕酮与妊娠关系的研究进展

朱杰,童先宏   

  1. 230001合肥，安徽医科大学附属省立医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-03-15 发布日期:2012-03-15

Effects of Progesterone on Pregnanc

ZHU Jie, TONG Xian -hong   

  1. Reproductive Medicine Center, Anhui Provincial Hospital Affiliated Anhui Medical University, Hefei 230001, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-03-15 Online:2012-03-15

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摘要： 成功的妊娠需要适当的母胎免疫耐受。随着妊娠的进展，孕酮作为一种免疫调节因子，作用于子宫内膜上皮细胞、基质细胞及子宫螺旋动脉，提供妊娠所需要的子宫微环境，并调节蜕膜树突细胞、T细胞与自然杀伤细胞的活性，上调滋养细胞膜人类白细胞抗原G免疫表达，诱导免疫耐受。因此，母体内孕酮的水平对正常妊娠的维持至关重要。

关键词: 孕酮, 免疫系统, 妊娠, 流产, 自然

Abstract: It is necessary to develop the proper fetal -maternal immune tolerance for successfulpregnancy. Along with the development of pregnancy, progesterone, as a kind of immune regulatory factor, actson end-ometrial epithelial and stromal cells and spiral arteries, which provides the uterine micro-environmentfor pregnancy. Meanwhile, progesterone regulates the activities of dendritic cells, T cells and natural killer cellsin deciduas, and up -regulates human leukocyte antigen G gene expression. The effects of progesteronesynthetically induced the immune tolerance. Thus, progesterone is critical for the maintenance of pregnancy.